Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature

Dowling-Degos disease (DDD) is an autosomal dominant disorder with variable phenotypic expression. Classically, DDD is characterized by progressive reticulate hyperpigmentation on flexures with perioral pitted scars and comedone-like hyperkeratotic papules. Follicular DDD is a rare variant which was...

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Autores principales:	Ya-Nin Nokdhes, Thanachat Rutnumnoi, Poramin Patthamalai, Charussri Leeyaphan
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	follicular dowling-degos disease hidradenitis suppurativa acne Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/395f546c54fb4cfd96e13077fe592568
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spelling	oai:doaj.org-article:395f546c54fb4cfd96e13077fe5925682021-12-02T12:40:22ZFollicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature1662-656710.1159/000520541https://doaj.org/article/395f546c54fb4cfd96e13077fe5925682021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520541https://doaj.org/toc/1662-6567Dowling-Degos disease (DDD) is an autosomal dominant disorder with variable phenotypic expression. Classically, DDD is characterized by progressive reticulate hyperpigmentation on flexures with perioral pitted scars and comedone-like hyperkeratotic papules. Follicular DDD is a rare variant which was introduced by Singh et al. [Indian J Dermatol Venereol Leprol. 2013 Nov–Dec;79(6):802–4]. Follicular DDD differs from other variants because of its notable comedone-like hyperkeratotic hyperpigmented papules and a distinct histopathology which demonstrates pigmented filiform and branching rete pegs originating at the follicular infundibulum with many epidermal horn cysts while the interfollicular epidermis is essentially normal. Hereby, we present a case of follicular DDD with hidradenitis suppurativa (HS). A 37-year-old Thai man presented with slowly progressive hyperpigmented comedone-like papules on the face, neck, axillae, upper trunk, and buttocks with perioral pitted scars. Punch biopsy from a comedonal lesion on his back was consistent with follicular DDD. He also had recurrent painful nodules and abscess on the back, groin, and buttock which matched the clinical criteria for the diagnosis of HS. To date, a paucity of concurrent DDD with HS has been reported. Recent genetic studies speculate a shared pathophysiologic mechanism of DDD and HS.Ya-Nin NokdhesThanachat RutnumnoiPoramin PatthamalaiCharussri LeeyaphanKarger Publishersarticlefollicular dowling-degos diseasehidradenitis suppurativaacneDermatologyRL1-803ENCase Reports in Dermatology, Vol 13, Iss 3, Pp 530-536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	follicular dowling-degos disease hidradenitis suppurativa acne Dermatology RL1-803
spellingShingle	follicular dowling-degos disease hidradenitis suppurativa acne Dermatology RL1-803 Ya-Nin Nokdhes Thanachat Rutnumnoi Poramin Patthamalai Charussri Leeyaphan Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
description	Dowling-Degos disease (DDD) is an autosomal dominant disorder with variable phenotypic expression. Classically, DDD is characterized by progressive reticulate hyperpigmentation on flexures with perioral pitted scars and comedone-like hyperkeratotic papules. Follicular DDD is a rare variant which was introduced by Singh et al. [Indian J Dermatol Venereol Leprol. 2013 Nov–Dec;79(6):802–4]. Follicular DDD differs from other variants because of its notable comedone-like hyperkeratotic hyperpigmented papules and a distinct histopathology which demonstrates pigmented filiform and branching rete pegs originating at the follicular infundibulum with many epidermal horn cysts while the interfollicular epidermis is essentially normal. Hereby, we present a case of follicular DDD with hidradenitis suppurativa (HS). A 37-year-old Thai man presented with slowly progressive hyperpigmented comedone-like papules on the face, neck, axillae, upper trunk, and buttocks with perioral pitted scars. Punch biopsy from a comedonal lesion on his back was consistent with follicular DDD. He also had recurrent painful nodules and abscess on the back, groin, and buttock which matched the clinical criteria for the diagnosis of HS. To date, a paucity of concurrent DDD with HS has been reported. Recent genetic studies speculate a shared pathophysiologic mechanism of DDD and HS.
format	article
author	Ya-Nin Nokdhes Thanachat Rutnumnoi Poramin Patthamalai Charussri Leeyaphan
author_facet	Ya-Nin Nokdhes Thanachat Rutnumnoi Poramin Patthamalai Charussri Leeyaphan
author_sort	Ya-Nin Nokdhes
title	Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
title_short	Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
title_full	Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
title_fullStr	Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
title_full_unstemmed	Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
title_sort	follicular dowling-degos disease with hidradenitis suppurativa: a case report and review of the literature
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/395f546c54fb4cfd96e13077fe592568
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Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature

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