Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

Background: Diabetes mellitus [DB] is a well-known risk factor for cardiovascular disease. The co-existence of DM and microvascular abnormalities could lead to hypertrophy of left ventricle (LV) with diastolic and/or systolic dysfunction. However, early stages of the disease are asymptomatic due to...

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Autores principales:	Wael Hassib, Mohamed Abd Elraouf, Reda Biomy, Mohammed Hamouda, Mohamed Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	diabetes mellitus left ventricle hepatitis c virus echocardiography direct anti-viral drugs Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/395f6790a6ed4d2b801a0026a0d08220
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spelling	oai:doaj.org-article:395f6790a6ed4d2b801a0026a0d082202021-12-02T17:05:58ZAssessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV2636-41742682-378010.21608/ijma.2021.80445.1326https://doaj.org/article/395f6790a6ed4d2b801a0026a0d082202021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_185109_8d0e28af1269beb1be54cd617b282bca.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Diabetes mellitus [DB] is a well-known risk factor for cardiovascular disease. The co-existence of DM and microvascular abnormalities could lead to hypertrophy of left ventricle (LV) with diastolic and/or systolic dysfunction. However, early stages of the disease are asymptomatic due to its chronic nature and the effective control of diabetes. Aim of the work: This clinical cohort aimed to assess left ventricular systolic function in DM patients, receiving direct acting antiviral (DAA) drugs for chronic hepatitis-C virus by speckle tracking. Subjects and methods: This clinical cohort included 90 patients who were divided into three equal groups. Patients were recruited from Hepatology Outpatient Clinic of Kafr El-Shaikh University hospital, who were sent to the cardiovascular department for evaluation. Patients were evaluated just before, one month and three months after starting therapy. Results: No one in control group had diastolic dysfunction compared to 10.0% and 16.7% in DAAs and Non-DAAs groups, respectively. Conventional echocardiography returned statistically non-significant difference except significant increase of LVESD, IVST and LVPWT in study groups than control groups. However, the difference between DAAs and Non-DAAs groups was statistically non-significant. The basic strain parameters returned significant lower values at different windows in control than study groups. The strains were reduced in the follow up visits (first and third months) in DAAs groups, but not significantly reduced in non-DAAs group. Acute myocardial infarction was reported among one patient in non-DAAs group compared to none in DAAs group. Conclusion: The speckle tracking is a useful tool for early detection of subclinical left ventricular dysfunction in HCV diabetic patients and could be used for following up of response DAA treatment. DAAs therapy is associated with improvement, not of HCV disease, but also of cardiac dysfunctionWael HassibMohamed Abd ElraoufReda BiomyMohammed HamoudaMohamed MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlediabetes mellitusleft ventriclehepatitis c virusechocardiographydirect anti-viral drugsMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1694-1699 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus left ventricle hepatitis c virus echocardiography direct anti-viral drugs Medicine (General) R5-920
spellingShingle	diabetes mellitus left ventricle hepatitis c virus echocardiography direct anti-viral drugs Medicine (General) R5-920 Wael Hassib Mohamed Abd Elraouf Reda Biomy Mohammed Hamouda Mohamed Mohamed Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
description	Background: Diabetes mellitus [DB] is a well-known risk factor for cardiovascular disease. The co-existence of DM and microvascular abnormalities could lead to hypertrophy of left ventricle (LV) with diastolic and/or systolic dysfunction. However, early stages of the disease are asymptomatic due to its chronic nature and the effective control of diabetes. Aim of the work: This clinical cohort aimed to assess left ventricular systolic function in DM patients, receiving direct acting antiviral (DAA) drugs for chronic hepatitis-C virus by speckle tracking. Subjects and methods: This clinical cohort included 90 patients who were divided into three equal groups. Patients were recruited from Hepatology Outpatient Clinic of Kafr El-Shaikh University hospital, who were sent to the cardiovascular department for evaluation. Patients were evaluated just before, one month and three months after starting therapy. Results: No one in control group had diastolic dysfunction compared to 10.0% and 16.7% in DAAs and Non-DAAs groups, respectively. Conventional echocardiography returned statistically non-significant difference except significant increase of LVESD, IVST and LVPWT in study groups than control groups. However, the difference between DAAs and Non-DAAs groups was statistically non-significant. The basic strain parameters returned significant lower values at different windows in control than study groups. The strains were reduced in the follow up visits (first and third months) in DAAs groups, but not significantly reduced in non-DAAs group. Acute myocardial infarction was reported among one patient in non-DAAs group compared to none in DAAs group. Conclusion: The speckle tracking is a useful tool for early detection of subclinical left ventricular dysfunction in HCV diabetic patients and could be used for following up of response DAA treatment. DAAs therapy is associated with improvement, not of HCV disease, but also of cardiac dysfunction
format	article
author	Wael Hassib Mohamed Abd Elraouf Reda Biomy Mohammed Hamouda Mohamed Mohamed
author_facet	Wael Hassib Mohamed Abd Elraouf Reda Biomy Mohammed Hamouda Mohamed Mohamed
author_sort	Wael Hassib
title	Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
title_short	Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
title_full	Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
title_fullStr	Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
title_full_unstemmed	Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV
title_sort	assessment of left ventricular systolic function by speckle tracking in diabetic patients receiving direct acting antiviral drugs for chronic hcv
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/395f6790a6ed4d2b801a0026a0d08220
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Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

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