Impact of PSCA variation on gastric ulcer susceptibility.
Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the...
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2013
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oai:doaj.org-article:3960e01c07124f9abc97f8400185a8f22021-11-18T07:44:52ZImpact of PSCA variation on gastric ulcer susceptibility.1932-620310.1371/journal.pone.0063698https://doaj.org/article/3960e01c07124f9abc97f8400185a8f22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23704932/?tool=EBIhttps://doaj.org/toc/1932-6203Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.Chizu TanikawaKeitaro MatsuoMichiaki KuboAtsushi TakahashiHidemi ItoHideo TanakaYasushi YatabeKenji YamaoNaoyuki KamataniKazuo TajimaYusuke NakamuraKoichi MatsudaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63698 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Chizu Tanikawa Keitaro Matsuo Michiaki Kubo Atsushi Takahashi Hidemi Ito Hideo Tanaka Yasushi Yatabe Kenji Yamao Naoyuki Kamatani Kazuo Tajima Yusuke Nakamura Koichi Matsuda Impact of PSCA variation on gastric ulcer susceptibility. |
| description |
Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers. |
| format |
article |
| author |
Chizu Tanikawa Keitaro Matsuo Michiaki Kubo Atsushi Takahashi Hidemi Ito Hideo Tanaka Yasushi Yatabe Kenji Yamao Naoyuki Kamatani Kazuo Tajima Yusuke Nakamura Koichi Matsuda |
| author_facet |
Chizu Tanikawa Keitaro Matsuo Michiaki Kubo Atsushi Takahashi Hidemi Ito Hideo Tanaka Yasushi Yatabe Kenji Yamao Naoyuki Kamatani Kazuo Tajima Yusuke Nakamura Koichi Matsuda |
| author_sort |
Chizu Tanikawa |
| title |
Impact of PSCA variation on gastric ulcer susceptibility. |
| title_short |
Impact of PSCA variation on gastric ulcer susceptibility. |
| title_full |
Impact of PSCA variation on gastric ulcer susceptibility. |
| title_fullStr |
Impact of PSCA variation on gastric ulcer susceptibility. |
| title_full_unstemmed |
Impact of PSCA variation on gastric ulcer susceptibility. |
| title_sort |
impact of psca variation on gastric ulcer susceptibility. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/3960e01c07124f9abc97f8400185a8f2 |
| work_keys_str_mv |
AT chizutanikawa impactofpscavariationongastriculcersusceptibility AT keitaromatsuo impactofpscavariationongastriculcersusceptibility AT michiakikubo impactofpscavariationongastriculcersusceptibility AT atsushitakahashi impactofpscavariationongastriculcersusceptibility AT hidemiito impactofpscavariationongastriculcersusceptibility AT hideotanaka impactofpscavariationongastriculcersusceptibility AT yasushiyatabe impactofpscavariationongastriculcersusceptibility AT kenjiyamao impactofpscavariationongastriculcersusceptibility AT naoyukikamatani impactofpscavariationongastriculcersusceptibility AT kazuotajima impactofpscavariationongastriculcersusceptibility AT yusukenakamura impactofpscavariationongastriculcersusceptibility AT koichimatsuda impactofpscavariationongastriculcersusceptibility |
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1718423029190492160 |