Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned from B cells of patients suffering candidiasis...

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Autores principales:	Fiona M. Rudkin, Ingrida Raziunaite, Hillary Workman, Sosthene Essono, Rodrigo Belmonte, Donna M. MacCallum, Elizabeth M. Johnson, Lisete M. Silva, Angelina S. Palma, Ten Feizi, Allan Jensen, Lars P. Erwig, Neil A. R. Gow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3962deb6cda443548deab4a2e58b1fbe
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spelling	oai:doaj.org-article:3962deb6cda443548deab4a2e58b1fbe2021-12-02T15:33:39ZSingle human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis10.1038/s41467-018-07738-12041-1723https://doaj.org/article/3962deb6cda443548deab4a2e58b1fbe2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07738-1https://doaj.org/toc/2041-1723Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned from B cells of patients suffering candidiasis.Fiona M. RudkinIngrida RaziunaiteHillary WorkmanSosthene EssonoRodrigo BelmonteDonna M. MacCallumElizabeth M. JohnsonLisete M. SilvaAngelina S. PalmaTen FeiziAllan JensenLars P. ErwigNeil A. R. GowNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fiona M. Rudkin Ingrida Raziunaite Hillary Workman Sosthene Essono Rodrigo Belmonte Donna M. MacCallum Elizabeth M. Johnson Lisete M. Silva Angelina S. Palma Ten Feizi Allan Jensen Lars P. Erwig Neil A. R. Gow Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
description	Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned from B cells of patients suffering candidiasis.
format	article
author	Fiona M. Rudkin Ingrida Raziunaite Hillary Workman Sosthene Essono Rodrigo Belmonte Donna M. MacCallum Elizabeth M. Johnson Lisete M. Silva Angelina S. Palma Ten Feizi Allan Jensen Lars P. Erwig Neil A. R. Gow
author_facet	Fiona M. Rudkin Ingrida Raziunaite Hillary Workman Sosthene Essono Rodrigo Belmonte Donna M. MacCallum Elizabeth M. Johnson Lisete M. Silva Angelina S. Palma Ten Feizi Allan Jensen Lars P. Erwig Neil A. R. Gow
author_sort	Fiona M. Rudkin
title	Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
title_short	Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
title_full	Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
title_fullStr	Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
title_full_unstemmed	Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
title_sort	single human b cell-derived monoclonal anti-candida antibodies enhance phagocytosis and protect against disseminated candidiasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3962deb6cda443548deab4a2e58b1fbe
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Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

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