Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study
Hiba Bawadi,1 Rami Katkhouda,2 Reema Tayyem,3 Abdelhamid Kerkadi,1 Samira Bou Raad,4 Hadil Subih5 1Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, Jorda...
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oai:doaj.org-article:39692798339145bfb160ee750b632f142021-12-02T09:35:25ZAbdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study1178-7007https://doaj.org/article/39692798339145bfb160ee750b632f142019-11-01T00:00:00Zhttps://www.dovepress.com/abdominal-fat-is-directly-associated-with-inflammation-in-persons-with-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hiba Bawadi,1 Rami Katkhouda,2 Reema Tayyem,3 Abdelhamid Kerkadi,1 Samira Bou Raad,4 Hadil Subih5 1Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Clinical Nutrition and Dietetics, University of Jordan, Amman, Jordan; 4Department of Nutrition and Food Science, American University of Science and Technology, Beirut, Lebanon; 5Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Hiba BawadiHuman Nutrition Department, College of Health Sciences, QU-Health, Qatar University, Building I06, University Street, PO Box 2713, Doha, QatarTel +97444034801Email hbawadi@qu.edu.qaBackground and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control.Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations ≥7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control.Results: Patients in <7% HbA1C category, those with high abdominal fat had ≈262% higher CRP and ≈30.6% higher IL-6 compared to those with low abdominal fat (p˂0.05). Patients in ≥7% HbA1C category, those with high abdominal fat had ≈41.4% higher CRP and ≈33.9% higher IL-6 compared to those with low abdominal fat (p˂0.05). Abdominal fat was directly related to CRP (p˂0.023) and IL-6 (p˂0.002) concentrations in both groups of type-2 diabetic patients with <7% and ≥7% HbA1C. In patients with ≥7% HbA1C, BMI was directly related to CRP (p˂0.02) and IL-6 (p˂0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations.Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control.Keywords: BMI, C-reactive protein, diabetes, IL-6, inflammation, obesityBawadi HKatkhouda RTayyem RKerkadi ABou Raad SSubih HDove Medical Pressarticlebmic-reactive proteindiabetesil-6inflammationobesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2411-2417 (2019) |
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bmi c-reactive protein diabetes il-6 inflammation obesity Specialties of internal medicine RC581-951 |
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bmi c-reactive protein diabetes il-6 inflammation obesity Specialties of internal medicine RC581-951 Bawadi H Katkhouda R Tayyem R Kerkadi A Bou Raad S Subih H Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study |
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Hiba Bawadi,1 Rami Katkhouda,2 Reema Tayyem,3 Abdelhamid Kerkadi,1 Samira Bou Raad,4 Hadil Subih5 1Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Clinical Nutrition and Dietetics, University of Jordan, Amman, Jordan; 4Department of Nutrition and Food Science, American University of Science and Technology, Beirut, Lebanon; 5Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Hiba BawadiHuman Nutrition Department, College of Health Sciences, QU-Health, Qatar University, Building I06, University Street, PO Box 2713, Doha, QatarTel +97444034801Email hbawadi@qu.edu.qaBackground and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control.Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations ≥7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control.Results: Patients in <7% HbA1C category, those with high abdominal fat had ≈262% higher CRP and ≈30.6% higher IL-6 compared to those with low abdominal fat (p˂0.05). Patients in ≥7% HbA1C category, those with high abdominal fat had ≈41.4% higher CRP and ≈33.9% higher IL-6 compared to those with low abdominal fat (p˂0.05). Abdominal fat was directly related to CRP (p˂0.023) and IL-6 (p˂0.002) concentrations in both groups of type-2 diabetic patients with <7% and ≥7% HbA1C. In patients with ≥7% HbA1C, BMI was directly related to CRP (p˂0.02) and IL-6 (p˂0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations.Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control.Keywords: BMI, C-reactive protein, diabetes, IL-6, inflammation, obesity |
| format |
article |
| author |
Bawadi H Katkhouda R Tayyem R Kerkadi A Bou Raad S Subih H |
| author_facet |
Bawadi H Katkhouda R Tayyem R Kerkadi A Bou Raad S Subih H |
| author_sort |
Bawadi H |
| title |
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic
Control – A Jordanian Study |
| title_short |
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic
Control – A Jordanian Study |
| title_full |
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic
Control – A Jordanian Study |
| title_fullStr |
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic
Control – A Jordanian Study |
| title_full_unstemmed |
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic
Control – A Jordanian Study |
| title_sort |
abdominal fat is directly associated with inflammation in persons with type-2 diabetes regardless of glycemic
control – a jordanian study |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/39692798339145bfb160ee750b632f14 |
| work_keys_str_mv |
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