Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes

Abstract In this study we conducted a cross sectional study to comprehensively evaluated the risk factors of chronic kidney disease (CKD) in a large sample of Chinese adults under primary care for type 2 diabetes mellitus (T2DM). We investigated the risk factors associated with the prevalence of CKD...

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Autores principales:	Lin Yang, Tsun Kit Chu, Jinxiao Lian, Cheuk Wai Lo, Pak Ki Lau, Hairong Nan, Jun Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Chinese Adults Type 2 Diabetes Mellitus (T2DM) Gender-specific Risk Factors Diabetic Retinopathy (DR) Coronary Heart Disease Medicine R Science Q
Acceso en línea:	https://doaj.org/article/396b83cdecd042c5bcadedc0e6d94c0f
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spelling	oai:doaj.org-article:396b83cdecd042c5bcadedc0e6d94c0f2021-12-02T15:08:05ZRisk factors of chronic kidney diseases in Chinese adults with type 2 diabetes10.1038/s41598-018-32983-12045-2322https://doaj.org/article/396b83cdecd042c5bcadedc0e6d94c0f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32983-1https://doaj.org/toc/2045-2322Abstract In this study we conducted a cross sectional study to comprehensively evaluated the risk factors of chronic kidney disease (CKD) in a large sample of Chinese adults under primary care for type 2 diabetes mellitus (T2DM). We investigated the risk factors associated with the prevalence of CKD in adults with T2DM, who were enrolled in the Risk Factor Assessment and Management Programme for Patients with Diabetes Mellitus (RAMP-DM) of Hong Kong from July 2014 to June 2017. We collected the individual data of 31,574 subjects, with mean age of 63.0 (±10.8) years and mean DM duration of 7.4 (±6.4) years. Of them 9,386 (29.7%) had CKD and 7,452 (23.6%) had micro- or macro-albuminuria. After adjustment for multiple demographic and lifestyle confounders, we identified several modifiable risk factors associated with higher rate of CKD: obesity (OR = 1.54), current smoking (OR = 1.33), higher systolic blood pressure (OR = 1.01), dyslipidemia (OR = 1.32 and 0.61 for triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C)), hyperglycemia (OR = 1.11 for HbA1c), diabetic retinopathy (OR = 1.36 and 2.60 for non-sight and sight threatening retinopathy), and stroke (OR = 1.43). The risk factors of lower dialytic blood pressure and coronary heart disease were identified only in men, whereas peripheral arterial disease only in women. In conclusion, several modifiable and gender specific risk factors were significantly associated with higher prevalence of CKD in Chinese adults with T2DM. The high-risk populations identified in this study shall receive regular screening for renal functions to achieve better patient management in primary care settings.Lin YangTsun Kit ChuJinxiao LianCheuk Wai LoPak Ki LauHairong NanJun LiangNature PortfolioarticleChinese AdultsType 2 Diabetes Mellitus (T2DM)Gender-specific Risk FactorsDiabetic Retinopathy (DR)Coronary Heart DiseaseMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chinese Adults Type 2 Diabetes Mellitus (T2DM) Gender-specific Risk Factors Diabetic Retinopathy (DR) Coronary Heart Disease Medicine R Science Q
spellingShingle	Chinese Adults Type 2 Diabetes Mellitus (T2DM) Gender-specific Risk Factors Diabetic Retinopathy (DR) Coronary Heart Disease Medicine R Science Q Lin Yang Tsun Kit Chu Jinxiao Lian Cheuk Wai Lo Pak Ki Lau Hairong Nan Jun Liang Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
description	Abstract In this study we conducted a cross sectional study to comprehensively evaluated the risk factors of chronic kidney disease (CKD) in a large sample of Chinese adults under primary care for type 2 diabetes mellitus (T2DM). We investigated the risk factors associated with the prevalence of CKD in adults with T2DM, who were enrolled in the Risk Factor Assessment and Management Programme for Patients with Diabetes Mellitus (RAMP-DM) of Hong Kong from July 2014 to June 2017. We collected the individual data of 31,574 subjects, with mean age of 63.0 (±10.8) years and mean DM duration of 7.4 (±6.4) years. Of them 9,386 (29.7%) had CKD and 7,452 (23.6%) had micro- or macro-albuminuria. After adjustment for multiple demographic and lifestyle confounders, we identified several modifiable risk factors associated with higher rate of CKD: obesity (OR = 1.54), current smoking (OR = 1.33), higher systolic blood pressure (OR = 1.01), dyslipidemia (OR = 1.32 and 0.61 for triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C)), hyperglycemia (OR = 1.11 for HbA1c), diabetic retinopathy (OR = 1.36 and 2.60 for non-sight and sight threatening retinopathy), and stroke (OR = 1.43). The risk factors of lower dialytic blood pressure and coronary heart disease were identified only in men, whereas peripheral arterial disease only in women. In conclusion, several modifiable and gender specific risk factors were significantly associated with higher prevalence of CKD in Chinese adults with T2DM. The high-risk populations identified in this study shall receive regular screening for renal functions to achieve better patient management in primary care settings.
format	article
author	Lin Yang Tsun Kit Chu Jinxiao Lian Cheuk Wai Lo Pak Ki Lau Hairong Nan Jun Liang
author_facet	Lin Yang Tsun Kit Chu Jinxiao Lian Cheuk Wai Lo Pak Ki Lau Hairong Nan Jun Liang
author_sort	Lin Yang
title	Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
title_short	Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
title_full	Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
title_fullStr	Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
title_full_unstemmed	Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
title_sort	risk factors of chronic kidney diseases in chinese adults with type 2 diabetes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/396b83cdecd042c5bcadedc0e6d94c0f
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_version_	1718388244956053504

Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes

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