Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone
The aim of the research was to study influence of dexamethasone and adrenaline on the concentration of energy metabolism substrates in blood of Chinchilla rabbits under the conditions of multiple skeletal trauma. We performed stabilization of the bones of right forearm and left shin in 35 animals by...
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Scientific Сentre for Family Health and Human Reproduction Problems
2013
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oai:doaj.org-article:397029aebb1841a68b9591fd261e78772021-11-23T06:14:29ZEnergy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone2541-94202587-9596https://doaj.org/article/397029aebb1841a68b9591fd261e78772013-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1658https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the research was to study influence of dexamethasone and adrenaline on the concentration of energy metabolism substrates in blood of Chinchilla rabbits under the conditions of multiple skeletal trauma. We performed stabilization of the bones of right forearm and left shin in 35 animals by wire external fixation device with further osteotomy of bones of corresponding segments. We observed the decrease of activity of metabolism in rabbits on the background of standard treatment. Maintenance of normal activity of metabolism by prescription of adrenaline and dexamethasone caused more intensive use of energy resources of an organism. Imitation of hyperergic reaction of stress-realizing systems in rabbits caused the increase of concentration of glucose in blood and the decrease of concentration of triglycerides. High consumption of energy substrates was provided by more expressed catabolic reaction. The result of hypercatabolism was development of hypoproteinemia, hypoalbuminemia and increase of the risk of fluid shift from bloodstream into the tissues with formation of organ insufficiency.S. N. BocharovM. L. LebedL. V. RodionovaM. G. KirpichenkoV. V. GumanenkoScientific Сentre for Family Health and Human Reproduction Problemsarticlerabbitsmultiple skeletal traumaglycemiatriglyceridemiablood plasma albumensScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 134-137 (2013) |
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DOAJ |
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RU |
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rabbits multiple skeletal trauma glycemia triglyceridemia blood plasma albumens Science Q |
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rabbits multiple skeletal trauma glycemia triglyceridemia blood plasma albumens Science Q S. N. Bocharov M. L. Lebed L. V. Rodionova M. G. Kirpichenko V. V. Gumanenko Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| description |
The aim of the research was to study influence of dexamethasone and adrenaline on the concentration of energy metabolism substrates in blood of Chinchilla rabbits under the conditions of multiple skeletal trauma. We performed stabilization of the bones of right forearm and left shin in 35 animals by wire external fixation device with further osteotomy of bones of corresponding segments. We observed the decrease of activity of metabolism in rabbits on the background of standard treatment. Maintenance of normal activity of metabolism by prescription of adrenaline and dexamethasone caused more intensive use of energy resources of an organism. Imitation of hyperergic reaction of stress-realizing systems in rabbits caused the increase of concentration of glucose in blood and the decrease of concentration of triglycerides. High consumption of energy substrates was provided by more expressed catabolic reaction. The result of hypercatabolism was development of hypoproteinemia, hypoalbuminemia and increase of the risk of fluid shift from bloodstream into the tissues with formation of organ insufficiency. |
| format |
article |
| author |
S. N. Bocharov M. L. Lebed L. V. Rodionova M. G. Kirpichenko V. V. Gumanenko |
| author_facet |
S. N. Bocharov M. L. Lebed L. V. Rodionova M. G. Kirpichenko V. V. Gumanenko |
| author_sort |
S. N. Bocharov |
| title |
Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| title_short |
Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| title_full |
Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| title_fullStr |
Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| title_full_unstemmed |
Energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| title_sort |
energy metabolism at experimental polytrauma: changes at the prescription of adrenaline and dexamethasone |
| publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
| publishDate |
2013 |
| url |
https://doaj.org/article/397029aebb1841a68b9591fd261e7877 |
| work_keys_str_mv |
AT snbocharov energymetabolismatexperimentalpolytraumachangesattheprescriptionofadrenalineanddexamethasone AT mllebed energymetabolismatexperimentalpolytraumachangesattheprescriptionofadrenalineanddexamethasone AT lvrodionova energymetabolismatexperimentalpolytraumachangesattheprescriptionofadrenalineanddexamethasone AT mgkirpichenko energymetabolismatexperimentalpolytraumachangesattheprescriptionofadrenalineanddexamethasone AT vvgumanenko energymetabolismatexperimentalpolytraumachangesattheprescriptionofadrenalineanddexamethasone |
| _version_ |
1718417124511186944 |