Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity

Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course and impairs the treatment response of these infla...

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Autores principales:	Zhuolin Guo, Yichun Yang, Yanhang Liao, Yulin Shi, Ling-juan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/39704bb18a6c40399411ee59c164c7d1
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spelling	oai:doaj.org-article:39704bb18a6c40399411ee59c164c7d12021-11-12T04:49:39ZEmerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity2667-026710.1016/j.xjidi.2021.100064https://doaj.org/article/39704bb18a6c40399411ee59c164c7d12022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667026721000655https://doaj.org/toc/2667-0267Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course and impairs the treatment response of these inflammatory skin diseases. Emerging evidence highlights that hypertrophied adipocytes and infiltrated immune cells secrete a variety of molecules, including fatty acids and adipokines, such as leptin, adiponectin, and a panel of cytokines/chemokines that modulate our immune system. In this review, we describe how adipose hypertrophy leads to a chronic low-grade inflammatory state in obesity and how obesity-related inflammatory factors are involved in the pathogenesis of PSO and/or AD. Finally, we discuss the potential role of antimicrobial peptides, mechanical stress and impairment of epidermal barrier function mediated by fast expansion, and dermal fat in modulating skin inflammation. Together, this review summarizes the current literature on how obesity is associated with the pathogenesis of PSO and AD, highlighting the potentially important but overlooked immunomodulatory role of adipose tissue in the skin.Zhuolin GuoYichun YangYanhang LiaoYulin ShiLing-juan ZhangElsevierarticleDermatologyRL1-803ENJID Innovations, Vol 2, Iss 1, Pp 100064- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Zhuolin Guo Yichun Yang Yanhang Liao Yulin Shi Ling-juan Zhang Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
description	Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course and impairs the treatment response of these inflammatory skin diseases. Emerging evidence highlights that hypertrophied adipocytes and infiltrated immune cells secrete a variety of molecules, including fatty acids and adipokines, such as leptin, adiponectin, and a panel of cytokines/chemokines that modulate our immune system. In this review, we describe how adipose hypertrophy leads to a chronic low-grade inflammatory state in obesity and how obesity-related inflammatory factors are involved in the pathogenesis of PSO and/or AD. Finally, we discuss the potential role of antimicrobial peptides, mechanical stress and impairment of epidermal barrier function mediated by fast expansion, and dermal fat in modulating skin inflammation. Together, this review summarizes the current literature on how obesity is associated with the pathogenesis of PSO and AD, highlighting the potentially important but overlooked immunomodulatory role of adipose tissue in the skin.
format	article
author	Zhuolin Guo Yichun Yang Yanhang Liao Yulin Shi Ling-juan Zhang
author_facet	Zhuolin Guo Yichun Yang Yanhang Liao Yulin Shi Ling-juan Zhang
author_sort	Zhuolin Guo
title	Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
title_short	Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
title_full	Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
title_fullStr	Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
title_full_unstemmed	Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
title_sort	emerging roles of adipose tissue in the pathogenesis of psoriasis and atopic dermatitis in obesity
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/39704bb18a6c40399411ee59c164c7d1
work_keys_str_mv	AT zhuolinguo emergingrolesofadiposetissueinthepathogenesisofpsoriasisandatopicdermatitisinobesity AT yichunyang emergingrolesofadiposetissueinthepathogenesisofpsoriasisandatopicdermatitisinobesity AT yanhangliao emergingrolesofadiposetissueinthepathogenesisofpsoriasisandatopicdermatitisinobesity AT yulinshi emergingrolesofadiposetissueinthepathogenesisofpsoriasisandatopicdermatitisinobesity AT lingjuanzhang emergingrolesofadiposetissueinthepathogenesisofpsoriasisandatopicdermatitisinobesity
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Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity

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