NcRNAs in Vascular and Valvular Intercellular Communication

Non-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNAs as regulators of different pathological pathways...

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Autores principales:	Benedikt Bartsch, Philip Roger Goody, Mohammed Rabiul Hosen, Denise Nehl, Neda Mohammadi, Andreas Zietzer, Philip Düsing, Alexander Pfeifer, Georg Nickenig, Felix Jansen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ncRNA atherosclerosis aortic stenosis endothelial dysfunction ncRNA therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3970af180b7a428b9fa75c53d17daea9
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id	oai:doaj.org-article:3970af180b7a428b9fa75c53d17daea9
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spelling	oai:doaj.org-article:3970af180b7a428b9fa75c53d17daea92021-11-05T14:11:05ZNcRNAs in Vascular and Valvular Intercellular Communication2296-889X10.3389/fmolb.2021.749681https://doaj.org/article/3970af180b7a428b9fa75c53d17daea92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.749681/fullhttps://doaj.org/toc/2296-889XNon-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNAs as regulators of different pathological pathways involved in endothelial dysfunction, cardiovascular inflammation, cell differentiation, and calcification. This review will discuss the role of protein-bound and extracellular vesicular-bound ncRNAs as biomarkers of vascular and valvular diseases, their role as intercellular communicators, and regulators of disease pathways and also highlights possible treatment strategies.Benedikt BartschPhilip Roger GoodyMohammed Rabiul HosenDenise NehlNeda MohammadiAndreas ZietzerPhilip DüsingAlexander PfeiferGeorg NickenigFelix JansenFrontiers Media S.A.articlencRNAatherosclerosisaortic stenosisendothelial dysfunctionncRNA therapyBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncRNA atherosclerosis aortic stenosis endothelial dysfunction ncRNA therapy Biology (General) QH301-705.5
spellingShingle	ncRNA atherosclerosis aortic stenosis endothelial dysfunction ncRNA therapy Biology (General) QH301-705.5 Benedikt Bartsch Philip Roger Goody Mohammed Rabiul Hosen Denise Nehl Neda Mohammadi Andreas Zietzer Philip Düsing Alexander Pfeifer Georg Nickenig Felix Jansen NcRNAs in Vascular and Valvular Intercellular Communication
description	Non-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNAs as regulators of different pathological pathways involved in endothelial dysfunction, cardiovascular inflammation, cell differentiation, and calcification. This review will discuss the role of protein-bound and extracellular vesicular-bound ncRNAs as biomarkers of vascular and valvular diseases, their role as intercellular communicators, and regulators of disease pathways and also highlights possible treatment strategies.
format	article
author	Benedikt Bartsch Philip Roger Goody Mohammed Rabiul Hosen Denise Nehl Neda Mohammadi Andreas Zietzer Philip Düsing Alexander Pfeifer Georg Nickenig Felix Jansen
author_facet	Benedikt Bartsch Philip Roger Goody Mohammed Rabiul Hosen Denise Nehl Neda Mohammadi Andreas Zietzer Philip Düsing Alexander Pfeifer Georg Nickenig Felix Jansen
author_sort	Benedikt Bartsch
title	NcRNAs in Vascular and Valvular Intercellular Communication
title_short	NcRNAs in Vascular and Valvular Intercellular Communication
title_full	NcRNAs in Vascular and Valvular Intercellular Communication
title_fullStr	NcRNAs in Vascular and Valvular Intercellular Communication
title_full_unstemmed	NcRNAs in Vascular and Valvular Intercellular Communication
title_sort	ncrnas in vascular and valvular intercellular communication
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3970af180b7a428b9fa75c53d17daea9
work_keys_str_mv	AT benediktbartsch ncrnasinvascularandvalvularintercellularcommunication AT philiprogergoody ncrnasinvascularandvalvularintercellularcommunication AT mohammedrabiulhosen ncrnasinvascularandvalvularintercellularcommunication AT denisenehl ncrnasinvascularandvalvularintercellularcommunication AT nedamohammadi ncrnasinvascularandvalvularintercellularcommunication AT andreaszietzer ncrnasinvascularandvalvularintercellularcommunication AT philipdusing ncrnasinvascularandvalvularintercellularcommunication AT alexanderpfeifer ncrnasinvascularandvalvularintercellularcommunication AT georgnickenig ncrnasinvascularandvalvularintercellularcommunication AT felixjansen ncrnasinvascularandvalvularintercellularcommunication
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NcRNAs in Vascular and Valvular Intercellular Communication

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