Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks

<b>The aim of the study was to investigate the distribution of prion protein <i>PRNP</i> alleles in flocks of Polish Merino and Suffolk sheep. The research was conducted in 2012-2017 on ewes and rams kept in the Golina Wielka sheepfold (Greater Poland Voivodeship, Poland). All anim...

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Autores principales: Roman Niżnikowski, Marcin Świątek, Żaneta Szymańska, Magdalena Ślęzak, Krzysztof Głowacz
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Publicado: Polish Society of Animal Production 2020
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spelling oai:doaj.org-article:397202f8501540ebac354045381c4bd72021-11-10T16:24:46ZPolymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks1733-73052719-393410.5604/01.3001.0014.2015https://doaj.org/article/397202f8501540ebac354045381c4bd72020-06-01T00:00:00Zhttp://zootechnical.com/gicid/01.3001.0014.2015http://zootechnical.com/gicid/pdf/01.3001.0014.2015https://doaj.org/toc/1733-7305https://doaj.org/toc/2719-3934<b>The aim of the study was to investigate the distribution of prion protein <i>PRNP</i> alleles in flocks of Polish Merino and Suffolk sheep. The research was conducted in 2012-2017 on ewes and rams kept in the Golina Wielka sheepfold (Greater Poland Voivodeship, Poland). All animals (264 ♀ and 64 ♂ Polish Merino; 98 ♀ and 73 ♂ Suffolk) were up to one year old. <i>PRNP</i> gene polymorphism was identified in the sheep. The frequency of scrapie alleles and genotypes was found to be highly significantly influenced by the breed and significantly influenced by the year in the case of Polish Merino sheep. Five alleles (ALRR, ALRQ, ALHQ, AFRQ and VLRQ) were detected in Polish Merino sheep, leading to the identification of 10 <i>PRNP</i> genotypes. In the Suffolk breed, three alleles (ALRR, ALRQ and ALHQ) and three genotypes were identified. In the Polish Merino breed, the frequency of the ALRR/ALRQ genotype was high and was the highest among all genotypes, followed by ALRR/ALRR. The level of genotypes containing valine at codon 136 was very low. In the Suffolk breed, the frequency of the ALRR/ALRR genotype was very high, and there were no alleles with valine at codon 136. In addition, in Polish Merino sheep, phenylalanine at codon 141 was detected only in the AFRQ allele, which appeared in two genotypes (in combination with ALRR and ALRQ).</b> Roman NiżnikowskiMarcin ŚwiątekŻaneta SzymańskaMagdalena ŚlęzakKrzysztof GłowaczPolish Society of Animal ProductionarticlesheepPRNPallele and genotype distributionZoologyQL1-991ENPLRoczniki Naukowe Polskiego Towarzystwa Zootechnicznego, Vol 16, Iss 2, Pp 9-21 (2020)
institution DOAJ
collection DOAJ
language EN
PL
topic sheep
PRNP
allele and genotype distribution
Zoology
QL1-991
spellingShingle sheep
PRNP
allele and genotype distribution
Zoology
QL1-991
Roman Niżnikowski
Marcin Świątek
Żaneta Szymańska
Magdalena Ślęzak
Krzysztof Głowacz
Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
description <b>The aim of the study was to investigate the distribution of prion protein <i>PRNP</i> alleles in flocks of Polish Merino and Suffolk sheep. The research was conducted in 2012-2017 on ewes and rams kept in the Golina Wielka sheepfold (Greater Poland Voivodeship, Poland). All animals (264 ♀ and 64 ♂ Polish Merino; 98 ♀ and 73 ♂ Suffolk) were up to one year old. <i>PRNP</i> gene polymorphism was identified in the sheep. The frequency of scrapie alleles and genotypes was found to be highly significantly influenced by the breed and significantly influenced by the year in the case of Polish Merino sheep. Five alleles (ALRR, ALRQ, ALHQ, AFRQ and VLRQ) were detected in Polish Merino sheep, leading to the identification of 10 <i>PRNP</i> genotypes. In the Suffolk breed, three alleles (ALRR, ALRQ and ALHQ) and three genotypes were identified. In the Polish Merino breed, the frequency of the ALRR/ALRQ genotype was high and was the highest among all genotypes, followed by ALRR/ALRR. The level of genotypes containing valine at codon 136 was very low. In the Suffolk breed, the frequency of the ALRR/ALRR genotype was very high, and there were no alleles with valine at codon 136. In addition, in Polish Merino sheep, phenylalanine at codon 141 was detected only in the AFRQ allele, which appeared in two genotypes (in combination with ALRR and ALRQ).</b>
format article
author Roman Niżnikowski
Marcin Świątek
Żaneta Szymańska
Magdalena Ślęzak
Krzysztof Głowacz
author_facet Roman Niżnikowski
Marcin Świątek
Żaneta Szymańska
Magdalena Ślęzak
Krzysztof Głowacz
author_sort Roman Niżnikowski
title Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
title_short Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
title_full Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
title_fullStr Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
title_full_unstemmed Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks
title_sort polymorphism of the prion protein gene (prnp) in polish merino and suffolk sheep flocks
publisher Polish Society of Animal Production
publishDate 2020
url https://doaj.org/article/397202f8501540ebac354045381c4bd7
work_keys_str_mv AT romanniznikowski polymorphismoftheprionproteingeneprnpinpolishmerinoandsuffolksheepflocks
AT marcinswiatek polymorphismoftheprionproteingeneprnpinpolishmerinoandsuffolksheepflocks
AT zanetaszymanska polymorphismoftheprionproteingeneprnpinpolishmerinoandsuffolksheepflocks
AT magdalenaslezak polymorphismoftheprionproteingeneprnpinpolishmerinoandsuffolksheepflocks
AT krzysztofgłowacz polymorphismoftheprionproteingeneprnpinpolishmerinoandsuffolksheepflocks
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