Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

Group I Paks, like Pak1, are required for the activation of several key oncogenic signaling pathways. Here the authors study an inducible peptide mimicking the auto-inhibitory domain of Pak1 and show promising anti-tumor effects in a mouse model of colorectal cancer.

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Detalles Bibliográficos
Autores principales:	H. Y. Chow, B. Dong, C. A. Valencia, C. T. Zeng, J. N. Koch, T. Y. Prudnikova, J. Chernoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3974d458c1394ee9a963760e6ec8129f
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spelling	oai:doaj.org-article:3974d458c1394ee9a963760e6ec8129f2021-12-02T15:34:01ZGroup I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer10.1038/s41467-018-05935-62041-1723https://doaj.org/article/3974d458c1394ee9a963760e6ec8129f2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05935-6https://doaj.org/toc/2041-1723Group I Paks, like Pak1, are required for the activation of several key oncogenic signaling pathways. Here the authors study an inducible peptide mimicking the auto-inhibitory domain of Pak1 and show promising anti-tumor effects in a mouse model of colorectal cancer.H. Y. ChowB. DongC. A. ValenciaC. T. ZengJ. N. KochT. Y. PrudnikovaJ. ChernoffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q H. Y. Chow B. Dong C. A. Valencia C. T. Zeng J. N. Koch T. Y. Prudnikova J. Chernoff Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
description	Group I Paks, like Pak1, are required for the activation of several key oncogenic signaling pathways. Here the authors study an inducible peptide mimicking the auto-inhibitory domain of Pak1 and show promising anti-tumor effects in a mouse model of colorectal cancer.
format	article
author	H. Y. Chow B. Dong C. A. Valencia C. T. Zeng J. N. Koch T. Y. Prudnikova J. Chernoff
author_facet	H. Y. Chow B. Dong C. A. Valencia C. T. Zeng J. N. Koch T. Y. Prudnikova J. Chernoff
author_sort	H. Y. Chow
title	Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
title_short	Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
title_full	Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
title_fullStr	Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
title_full_unstemmed	Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
title_sort	group i paks are essential for epithelial- mesenchymal transition in an apc-driven model of colorectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3974d458c1394ee9a963760e6ec8129f
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Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

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