Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

Group I Paks, like Pak1, are required for the activation of several key oncogenic signaling pathways. Here the authors study an inducible peptide mimicking the auto-inhibitory domain of Pak1 and show promising anti-tumor effects in a mouse model of colorectal cancer.

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Bibliographic Details
Main Authors: H. Y. Chow, B. Dong, C. A. Valencia, C. T. Zeng, J. N. Koch, T. Y. Prudnikova, J. Chernoff
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/3974d458c1394ee9a963760e6ec8129f
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