The association between FTO rs9939609 polymorphism and serum lipid profile in adult women
Abstract Background FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile. Therefore, this study aimed to investigate the association of FTO rs9939609 poly...
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2021
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oai:doaj.org-article:397651035b124009a52aed89210b0eec2021-11-21T12:40:19ZThe association between FTO rs9939609 polymorphism and serum lipid profile in adult women10.1186/s13098-021-00754-01758-5996https://doaj.org/article/397651035b124009a52aed89210b0eec2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00754-0https://doaj.org/toc/1758-5996Abstract Background FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile. Therefore, this study aimed to investigate the association of FTO rs9939609 polymorphism with lipid profile in Iranian women. Methods This cross-sectional study was carried out on 380 adult women. Information about age, height, weight, BMI, physical activity, and dietary intake were collected. The serum levels of Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Triglyceride (TG), and total cholesterol were measured. The FTO gene was genotyped for rs9939609 polymorphism. The participants were divided into two groups of TT and AT/AA considering dominant model of FTO rs9939609 polymorphism. Results General characteristics of the participants with different FTO genotypes were not significantly different. The lower levels of HDL were observed in AT/AA genotypes compared to the TT wild type genotype of FTO rs9939609 polymorphism (P = 0.004). Adjustments of age, BMI, and physical activity did not change the results. Conclusions However, the significant association between FTO genotype and the HDL level was disappeared after further adjustments for dietary intake. Further studies are warranted to identify the underlying mechanisms of the possible association between FTO gene and serum lipid profile.Vahideh JaliliZohreh MokhtariSamira RastgooAzadeh HajipourFatemeh BourbourMaryam GholamalizadehAlireza Mosavi JarrahiSepehr JavadiKoosheshAlireza MoslemMorteza AbdollahiSaeid DoaeiBMCarticleFTO geneSerum lipidsPolymorphismNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-6 (2021) |
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DOAJ |
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EN |
| topic |
FTO gene Serum lipids Polymorphism Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
FTO gene Serum lipids Polymorphism Nutritional diseases. Deficiency diseases RC620-627 Vahideh Jalili Zohreh Mokhtari Samira Rastgoo Azadeh Hajipour Fatemeh Bourbour Maryam Gholamalizadeh Alireza Mosavi Jarrahi Sepehr JavadiKooshesh Alireza Moslem Morteza Abdollahi Saeid Doaei The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| description |
Abstract Background FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile. Therefore, this study aimed to investigate the association of FTO rs9939609 polymorphism with lipid profile in Iranian women. Methods This cross-sectional study was carried out on 380 adult women. Information about age, height, weight, BMI, physical activity, and dietary intake were collected. The serum levels of Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Triglyceride (TG), and total cholesterol were measured. The FTO gene was genotyped for rs9939609 polymorphism. The participants were divided into two groups of TT and AT/AA considering dominant model of FTO rs9939609 polymorphism. Results General characteristics of the participants with different FTO genotypes were not significantly different. The lower levels of HDL were observed in AT/AA genotypes compared to the TT wild type genotype of FTO rs9939609 polymorphism (P = 0.004). Adjustments of age, BMI, and physical activity did not change the results. Conclusions However, the significant association between FTO genotype and the HDL level was disappeared after further adjustments for dietary intake. Further studies are warranted to identify the underlying mechanisms of the possible association between FTO gene and serum lipid profile. |
| format |
article |
| author |
Vahideh Jalili Zohreh Mokhtari Samira Rastgoo Azadeh Hajipour Fatemeh Bourbour Maryam Gholamalizadeh Alireza Mosavi Jarrahi Sepehr JavadiKooshesh Alireza Moslem Morteza Abdollahi Saeid Doaei |
| author_facet |
Vahideh Jalili Zohreh Mokhtari Samira Rastgoo Azadeh Hajipour Fatemeh Bourbour Maryam Gholamalizadeh Alireza Mosavi Jarrahi Sepehr JavadiKooshesh Alireza Moslem Morteza Abdollahi Saeid Doaei |
| author_sort |
Vahideh Jalili |
| title |
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| title_short |
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| title_full |
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| title_fullStr |
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| title_full_unstemmed |
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women |
| title_sort |
association between fto rs9939609 polymorphism and serum lipid profile in adult women |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/397651035b124009a52aed89210b0eec |
| work_keys_str_mv |
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