Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8+ T cell memory.

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Autores principales:	Adam T. Waickman, Kaitlin Victor, Tao Li, Kristin Hatch, Wiriya Rutvisuttinunt, Carey Medin, Benjamin Gabriel, Richard G. Jarman, Heather Friberg, Jeffrey R. Currier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/397665ccccdd42deb850a4519fa9b750
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spelling	oai:doaj.org-article:397665ccccdd42deb850a4519fa9b7502021-12-02T17:01:40ZDissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling10.1038/s41467-019-11634-72041-1723https://doaj.org/article/397665ccccdd42deb850a4519fa9b7502019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11634-7https://doaj.org/toc/2041-1723Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8+ T cell memory.Adam T. WaickmanKaitlin VictorTao LiKristin HatchWiriya RutvisuttinuntCarey MedinBenjamin GabrielRichard G. JarmanHeather FribergJeffrey R. CurrierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam T. Waickman Kaitlin Victor Tao Li Kristin Hatch Wiriya Rutvisuttinunt Carey Medin Benjamin Gabriel Richard G. Jarman Heather Friberg Jeffrey R. Currier Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
description	Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8+ T cell memory.
format	article
author	Adam T. Waickman Kaitlin Victor Tao Li Kristin Hatch Wiriya Rutvisuttinunt Carey Medin Benjamin Gabriel Richard G. Jarman Heather Friberg Jeffrey R. Currier
author_facet	Adam T. Waickman Kaitlin Victor Tao Li Kristin Hatch Wiriya Rutvisuttinunt Carey Medin Benjamin Gabriel Richard G. Jarman Heather Friberg Jeffrey R. Currier
author_sort	Adam T. Waickman
title	Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
title_short	Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
title_full	Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
title_fullStr	Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
title_full_unstemmed	Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
title_sort	dissecting the heterogeneity of denv vaccine-elicited cellular immunity using single-cell rna sequencing and metabolic profiling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/397665ccccdd42deb850a4519fa9b750
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Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

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