Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8+ T cell memory.

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Detalles Bibliográficos
Autores principales: Adam T. Waickman, Kaitlin Victor, Tao Li, Kristin Hatch, Wiriya Rutvisuttinunt, Carey Medin, Benjamin Gabriel, Richard G. Jarman, Heather Friberg, Jeffrey R. Currier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/397665ccccdd42deb850a4519fa9b750
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