Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by pre...

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Autores principales:	Yundong He, Shihong Peng, Jinhua Wang, Huang Chen, Xiaonan Cong, Ang Chen, Meichun Hu, Min Qin, Haigang Wu, Shuman Gao, Liguo Wang, Xin Wang, Zhengfang Yi, Mingyao Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/397854b72c3a42d8b708521339c3ef2d
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spelling	oai:doaj.org-article:397854b72c3a42d8b708521339c3ef2d2021-12-02T16:49:56ZAilanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer10.1038/ncomms131222041-1723https://doaj.org/article/397854b72c3a42d8b708521339c3ef2d2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13122https://doaj.org/toc/2041-1723Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by preventing AR interaction with HSP90, results in ubiquitin/proteasome-mediated degradation of the receptor.Yundong HeShihong PengJinhua WangHuang ChenXiaonan CongAng ChenMeichun HuMin QinHaigang WuShuman GaoLiguo WangXin WangZhengfang YiMingyao LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yundong He Shihong Peng Jinhua Wang Huang Chen Xiaonan Cong Ang Chen Meichun Hu Min Qin Haigang Wu Shuman Gao Liguo Wang Xin Wang Zhengfang Yi Mingyao Liu Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
description	Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by preventing AR interaction with HSP90, results in ubiquitin/proteasome-mediated degradation of the receptor.
format	article
author	Yundong He Shihong Peng Jinhua Wang Huang Chen Xiaonan Cong Ang Chen Meichun Hu Min Qin Haigang Wu Shuman Gao Liguo Wang Xin Wang Zhengfang Yi Mingyao Liu
author_facet	Yundong He Shihong Peng Jinhua Wang Huang Chen Xiaonan Cong Ang Chen Meichun Hu Min Qin Haigang Wu Shuman Gao Liguo Wang Xin Wang Zhengfang Yi Mingyao Liu
author_sort	Yundong He
title	Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
title_short	Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
title_full	Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
title_fullStr	Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
title_full_unstemmed	Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
title_sort	ailanthone targets p23 to overcome mdv3100 resistance in castration-resistant prostate cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/397854b72c3a42d8b708521339c3ef2d
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Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

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