Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer
Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by pre...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
|
| Subjects: | |
| Online Access: | https://doaj.org/article/397854b72c3a42d8b708521339c3ef2d |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|