Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Lung development occurs under relative hypoxia and the most important oxygen-sensitive response pathway is driven by Hypoxia Inducible Factors (HIF). HIFs are heterodimeric transcription factors of an oxygen-sensitive subunit, HIFα, and a constitutively expressed subunit, HIF1β. HIF1α and HIF2α, enc...

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Autores principales: Yadi Huang, Joshua Kapere Ochieng, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Sigrid Swagemakers, Wilfred van Ijcken, Frank Grosveld, Dick Tibboel, Robbert J Rottier
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/397e9de8d6e94fe9b34cf36eb17a1f6f
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