Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f |
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oai:doaj.org-article:397f4e630bac42c587fdf199a5689e3f2021-12-02T15:33:43ZInhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy10.1038/s41467-018-05763-82041-1723https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05763-8https://doaj.org/toc/2041-1723IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.Susan E. LogueEoghan P. McGrathPatricia ClearyStephanie GreeneKatarzyna MnichAitor AlmanzaEric ChevetRóisín M. DwyerAnup OommenPatrick LegembreFlorence GodeyEmma C. MaddenBrian LeuzziJoanna ObaczQingping ZengJohn B. PattersonRichard JägerAdrienne M. GormanAfshin SamaliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| description |
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC. |
| format |
article |
| author |
Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali |
| author_facet |
Susan E. Logue Eoghan P. McGrath Patricia Cleary Stephanie Greene Katarzyna Mnich Aitor Almanza Eric Chevet Róisín M. Dwyer Anup Oommen Patrick Legembre Florence Godey Emma C. Madden Brian Leuzzi Joanna Obacz Qingping Zeng John B. Patterson Richard Jäger Adrienne M. Gorman Afshin Samali |
| author_sort |
Susan E. Logue |
| title |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_short |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_full |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_fullStr |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_full_unstemmed |
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| title_sort |
inhibition of ire1 rnase activity modulates the tumor cell secretome and enhances response to chemotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f |
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1718387016782053376 |