In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.

Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate the in vitro activ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sacha J Pidot, Jessica L Porter, Troy Lister, Timothy P Stinear
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/397f639d3bc44abdb93f406b27d55243
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:397f639d3bc44abdb93f406b27d55243
record_format	dspace
spelling	oai:doaj.org-article:397f639d3bc44abdb93f406b27d552432021-11-25T06:33:28ZIn vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.1935-27271935-273510.1371/journal.pntd.0009636https://doaj.org/article/397f639d3bc44abdb93f406b27d552432021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009636https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate the in vitro activity of SPR719, a novel aminobenzimidazole antibiotic and the active form of the clinical-stage compound, SPR720, against several isolates of Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera. We show that SPR719 is active against these NTM species with a MIC range of 0.125-4 μg/ml and that this compares favorably with the commonly utilized antimycobacterial antibiotics, rifampicin and clarithromycin. Our findings suggest that SPR720 should be further evaluated for the treatment of NTM infections.Sacha J PidotJessica L PorterTroy ListerTimothy P StinearPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009636 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sacha J Pidot Jessica L Porter Troy Lister Timothy P Stinear In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
description	Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate the in vitro activity of SPR719, a novel aminobenzimidazole antibiotic and the active form of the clinical-stage compound, SPR720, against several isolates of Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera. We show that SPR719 is active against these NTM species with a MIC range of 0.125-4 μg/ml and that this compares favorably with the commonly utilized antimycobacterial antibiotics, rifampicin and clarithromycin. Our findings suggest that SPR720 should be further evaluated for the treatment of NTM infections.
format	article
author	Sacha J Pidot Jessica L Porter Troy Lister Timothy P Stinear
author_facet	Sacha J Pidot Jessica L Porter Troy Lister Timothy P Stinear
author_sort	Sacha J Pidot
title	In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
title_short	In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
title_full	In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
title_fullStr	In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
title_full_unstemmed	In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.
title_sort	in vitro activity of spr719 against mycobacterium ulcerans, mycobacterium marinum and mycobacterium chimaera.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/397f639d3bc44abdb93f406b27d55243
work_keys_str_mv	AT sachajpidot invitroactivityofspr719againstmycobacteriumulceransmycobacteriummarinumandmycobacteriumchimaera AT jessicalporter invitroactivityofspr719againstmycobacteriumulceransmycobacteriummarinumandmycobacteriumchimaera AT troylister invitroactivityofspr719againstmycobacteriumulceransmycobacteriummarinumandmycobacteriumchimaera AT timothypstinear invitroactivityofspr719againstmycobacteriumulceransmycobacteriummarinumandmycobacteriumchimaera
_version_	1718413612214648832

In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.

Ejemplares similares