Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

Meningitis is a severe form of invasive pneumococcal disease (IPD). To study the contribution of bacterial genomic variation, here Li et al. perform whole genome sequencing of pneumococcal isolates from IPD patients and identify an association for higher risk of meningitis with a pbp1bA641C variant

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Autores principales:	Yuan Li, Benjamin J. Metcalf, Sopio Chochua, Zhongya Li, Hollis Walker, Theresa Tran, Paulina A. Hawkins, Ryan Gierke, Tamara Pilishvili, Lesley McGee, Bernard W. Beall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3981a36b97a44b1f8420f9609ccbf4bd
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spelling	oai:doaj.org-article:3981a36b97a44b1f8420f9609ccbf4bd2021-12-02T16:58:06ZGenome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis10.1038/s41467-018-07997-y2041-1723https://doaj.org/article/3981a36b97a44b1f8420f9609ccbf4bd2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07997-yhttps://doaj.org/toc/2041-1723Meningitis is a severe form of invasive pneumococcal disease (IPD). To study the contribution of bacterial genomic variation, here Li et al. perform whole genome sequencing of pneumococcal isolates from IPD patients and identify an association for higher risk of meningitis with a pbp1bA641C variantYuan LiBenjamin J. MetcalfSopio ChochuaZhongya LiHollis WalkerTheresa TranPaulina A. HawkinsRyan GierkeTamara PilishviliLesley McGeeBernard W. BeallNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Li Benjamin J. Metcalf Sopio Chochua Zhongya Li Hollis Walker Theresa Tran Paulina A. Hawkins Ryan Gierke Tamara Pilishvili Lesley McGee Bernard W. Beall Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
description	Meningitis is a severe form of invasive pneumococcal disease (IPD). To study the contribution of bacterial genomic variation, here Li et al. perform whole genome sequencing of pneumococcal isolates from IPD patients and identify an association for higher risk of meningitis with a pbp1bA641C variant
format	article
author	Yuan Li Benjamin J. Metcalf Sopio Chochua Zhongya Li Hollis Walker Theresa Tran Paulina A. Hawkins Ryan Gierke Tamara Pilishvili Lesley McGee Bernard W. Beall
author_facet	Yuan Li Benjamin J. Metcalf Sopio Chochua Zhongya Li Hollis Walker Theresa Tran Paulina A. Hawkins Ryan Gierke Tamara Pilishvili Lesley McGee Bernard W. Beall
author_sort	Yuan Li
title	Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
title_short	Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
title_full	Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
title_fullStr	Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
title_full_unstemmed	Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
title_sort	genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3981a36b97a44b1f8420f9609ccbf4bd
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Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

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