Biomarkers in traumatic brain injury (TBI): a review

Aaron Dadas,1 Jolewis Washington,1 Ramon Diaz-Arrastia,2 Damir Janigro1,3 1FloTBI Inc., Cleveland, OH, USA; 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Physiology, Case Western Reserve University, Cleveland, OH, USA Abstract: Biomarkers can be broadl...

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Autores principales:	Dadas A, Washington J, Diaz-Arrastia R, Janigro D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	peripheral markers – blood-brain barrier – post-traumatic epilepsy – fluid biomarkers – mild traumatic brain injury - neuroimaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/39865b3625094172869136d0b93b40aa
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spelling	oai:doaj.org-article:39865b3625094172869136d0b93b40aa2021-12-02T00:01:48ZBiomarkers in traumatic brain injury (TBI): a review1178-2021https://doaj.org/article/39865b3625094172869136d0b93b40aa2018-11-01T00:00:00Zhttps://www.dovepress.com/biomarkers-in-traumatic-brain-injury-tbi-a-review-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Aaron Dadas,1 Jolewis Washington,1 Ramon Diaz-Arrastia,2 Damir Janigro1,3 1FloTBI Inc., Cleveland, OH, USA; 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Physiology, Case Western Reserve University, Cleveland, OH, USA Abstract: Biomarkers can be broadly defined as qualitative or quantitative measurements that convey information on the physiopathological state of a subject at a certain time point or disease state. Biomarkers can indicate health, pathology, or response to treatment, including unwanted side effects. When used as outcomes in clinical trials, biomarkers act as surrogates or substitutes for clinically meaningful endpoints. Biomarkers of disease can be diagnostic (the identification of the nature and cause of a condition) or prognostic (predicting the likelihood of a person’s survival or outcome of a disease). In addition, genetic biomarkers can be used to quantify the risk of developing a certain disease. In the specific case of traumatic brain injury, surrogate blood biomarkers of imaging can improve the standard of care and reduce the costs of diagnosis. In addition, a prognostic role for biomarkers has been suggested in the case of post-traumatic epilepsy. Given the extensive literature on clinical biomarkers, we will focus herein on biomarkers which are present in peripheral body fluids such as saliva and blood. In particular, blood biomarkers, such as glial fibrillary acidic protein and salivary/blood S100B, will be discussed together with the use of nucleic acids (eg, DNA) collected from peripheral cells. Keywords: peripheral markers, blood–brain barrier, post-traumatic epilepsy, fluid biomarkers, mild traumatic brain injury, neuroimagingDadas AWashington JDiaz-Arrastia RJanigro DDove Medical Pressarticleperipheral markers – blood-brain barrier – post-traumatic epilepsy – fluid biomarkers – mild traumatic brain injury - neuroimagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2989-3000 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	peripheral markers – blood-brain barrier – post-traumatic epilepsy – fluid biomarkers – mild traumatic brain injury - neuroimaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	peripheral markers – blood-brain barrier – post-traumatic epilepsy – fluid biomarkers – mild traumatic brain injury - neuroimaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dadas A Washington J Diaz-Arrastia R Janigro D Biomarkers in traumatic brain injury (TBI): a review
description	Aaron Dadas,1 Jolewis Washington,1 Ramon Diaz-Arrastia,2 Damir Janigro1,3 1FloTBI Inc., Cleveland, OH, USA; 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Physiology, Case Western Reserve University, Cleveland, OH, USA Abstract: Biomarkers can be broadly defined as qualitative or quantitative measurements that convey information on the physiopathological state of a subject at a certain time point or disease state. Biomarkers can indicate health, pathology, or response to treatment, including unwanted side effects. When used as outcomes in clinical trials, biomarkers act as surrogates or substitutes for clinically meaningful endpoints. Biomarkers of disease can be diagnostic (the identification of the nature and cause of a condition) or prognostic (predicting the likelihood of a person’s survival or outcome of a disease). In addition, genetic biomarkers can be used to quantify the risk of developing a certain disease. In the specific case of traumatic brain injury, surrogate blood biomarkers of imaging can improve the standard of care and reduce the costs of diagnosis. In addition, a prognostic role for biomarkers has been suggested in the case of post-traumatic epilepsy. Given the extensive literature on clinical biomarkers, we will focus herein on biomarkers which are present in peripheral body fluids such as saliva and blood. In particular, blood biomarkers, such as glial fibrillary acidic protein and salivary/blood S100B, will be discussed together with the use of nucleic acids (eg, DNA) collected from peripheral cells. Keywords: peripheral markers, blood–brain barrier, post-traumatic epilepsy, fluid biomarkers, mild traumatic brain injury, neuroimaging
format	article
author	Dadas A Washington J Diaz-Arrastia R Janigro D
author_facet	Dadas A Washington J Diaz-Arrastia R Janigro D
author_sort	Dadas A
title	Biomarkers in traumatic brain injury (TBI): a review
title_short	Biomarkers in traumatic brain injury (TBI): a review
title_full	Biomarkers in traumatic brain injury (TBI): a review
title_fullStr	Biomarkers in traumatic brain injury (TBI): a review
title_full_unstemmed	Biomarkers in traumatic brain injury (TBI): a review
title_sort	biomarkers in traumatic brain injury (tbi): a review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/39865b3625094172869136d0b93b40aa
work_keys_str_mv	AT dadasa biomarkersintraumaticbraininjurytbiareview AT washingtonj biomarkersintraumaticbraininjurytbiareview AT diazarrastiar biomarkersintraumaticbraininjurytbiareview AT janigrod biomarkersintraumaticbraininjurytbiareview
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Biomarkers in traumatic brain injury (TBI): a review

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