The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.

<h4>Objectives</h4>Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan...

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Autores principales:	Omayma Siddig, Mayson B Mustafa, Yousif Kordofani, John Gibson, Ahmed M Suleiman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/398d1bea790a406392e9a952dbd6574b
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spelling	oai:doaj.org-article:398d1bea790a406392e9a952dbd6574b2021-12-02T20:15:23ZThe epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.1932-620310.1371/journal.pone.0254634https://doaj.org/article/398d1bea790a406392e9a952dbd6574b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254634https://doaj.org/toc/1932-6203<h4>Objectives</h4>Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan.<h4>Methods</h4>This was a retrospective cross-sectional study conducted at Khartoum Dermatological and Venereal Diseases Teaching Hospital. We used routinely collected health care data, and included all patients with an autoimmune bullous disease who presented to the hospital between 2001 and 2016.<h4>Results</h4>Out of the 4736 patients who were admitted to the hospital during the study period, 923 (19.5%) had an autoimmune bullous disease. The average rate of patients at the hospital was 57.7 per year representing 1.3 per 100,000 population per year. After exclusion of patients where the final diagnosis was missing, 585 were included in the further analysis. Pemphigus vulgaris was the most common disease (50.9%), followed by bullous pemphigoid (28.2%), linear IgA disease/chronic bullous disease of childhood (8.4%), and pemphigus foliaceous (8.2%). Pemphigoid gestationis and IgA pemphigus constituted 1.4% and 1.2% of the cohort, respectively. Paraneoplastic pemphigus, mucous membrane pemphigoid, lichen planus pemphigoidis, bullous systemic lupus erythematosus, and dermatitis herpetiformis were rare. None of the patients had epidermolysis bullosa acquisita.<h4>Conclusions</h4>The clinico-epidemiological characteristics vary among the types of autoimmune bullous diseases. Females were more predominant in most of them. Sudanese patients tended in general to present at a younger age than other populations. The pool of Sudanese patients with autoimmune bullous diseases is large which requires investigation for the local risk factors and presents a field for future trials.Omayma SiddigMayson B MustafaYousif KordofaniJohn GibsonAhmed M SuleimanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254634 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Omayma Siddig Mayson B Mustafa Yousif Kordofani John Gibson Ahmed M Suleiman The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
description	<h4>Objectives</h4>Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan.<h4>Methods</h4>This was a retrospective cross-sectional study conducted at Khartoum Dermatological and Venereal Diseases Teaching Hospital. We used routinely collected health care data, and included all patients with an autoimmune bullous disease who presented to the hospital between 2001 and 2016.<h4>Results</h4>Out of the 4736 patients who were admitted to the hospital during the study period, 923 (19.5%) had an autoimmune bullous disease. The average rate of patients at the hospital was 57.7 per year representing 1.3 per 100,000 population per year. After exclusion of patients where the final diagnosis was missing, 585 were included in the further analysis. Pemphigus vulgaris was the most common disease (50.9%), followed by bullous pemphigoid (28.2%), linear IgA disease/chronic bullous disease of childhood (8.4%), and pemphigus foliaceous (8.2%). Pemphigoid gestationis and IgA pemphigus constituted 1.4% and 1.2% of the cohort, respectively. Paraneoplastic pemphigus, mucous membrane pemphigoid, lichen planus pemphigoidis, bullous systemic lupus erythematosus, and dermatitis herpetiformis were rare. None of the patients had epidermolysis bullosa acquisita.<h4>Conclusions</h4>The clinico-epidemiological characteristics vary among the types of autoimmune bullous diseases. Females were more predominant in most of them. Sudanese patients tended in general to present at a younger age than other populations. The pool of Sudanese patients with autoimmune bullous diseases is large which requires investigation for the local risk factors and presents a field for future trials.
format	article
author	Omayma Siddig Mayson B Mustafa Yousif Kordofani John Gibson Ahmed M Suleiman
author_facet	Omayma Siddig Mayson B Mustafa Yousif Kordofani John Gibson Ahmed M Suleiman
author_sort	Omayma Siddig
title	The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
title_short	The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
title_full	The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
title_fullStr	The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
title_full_unstemmed	The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.
title_sort	epidemiology of autoimmune bullous diseases in sudan between 2000 and 2016.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/398d1bea790a406392e9a952dbd6574b
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The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.

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