Brief bursts self-inhibit and correlate the pyramidal network.

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect...

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Autores principales:	Thomas K Berger, Gilad Silberberg, Rodrigo Perin, Henry Markram
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/398da57b31c3496c8b14e6fe046a0b9f
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id	oai:doaj.org-article:398da57b31c3496c8b14e6fe046a0b9f
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spelling	oai:doaj.org-article:398da57b31c3496c8b14e6fe046a0b9f2021-11-18T05:34:52ZBrief bursts self-inhibit and correlate the pyramidal network.1544-91731545-788510.1371/journal.pbio.1000473https://doaj.org/article/398da57b31c3496c8b14e6fe046a0b9f2010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838653/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequency-dependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti cells (MCs). Here, we show that simultaneous short bursts in four PCs are sufficient to exert FDDI in all neighboring PCs within the dimensions of a cortical column. This powerful inhibition is mediated by few interneurons, leading to strongly correlated membrane fluctuations and synchronous spiking between PCs simultaneously receiving FDDI. Somatic integration of such inhibition is independent and electrically isolated from monosynaptic excitation formed between the same PCs. FDDI is strongly shaped by I(h) in PC dendrites, which determines the effective integration time window for inhibitory and excitatory inputs. We propose a key disynaptic mechanism by which brief bursts generated by a few PCs can synchronize the activity in the pyramidal network.Thomas K BergerGilad SilberbergRodrigo PerinHenry MarkramPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 9 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Thomas K Berger Gilad Silberberg Rodrigo Perin Henry Markram Brief bursts self-inhibit and correlate the pyramidal network.
description	Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequency-dependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti cells (MCs). Here, we show that simultaneous short bursts in four PCs are sufficient to exert FDDI in all neighboring PCs within the dimensions of a cortical column. This powerful inhibition is mediated by few interneurons, leading to strongly correlated membrane fluctuations and synchronous spiking between PCs simultaneously receiving FDDI. Somatic integration of such inhibition is independent and electrically isolated from monosynaptic excitation formed between the same PCs. FDDI is strongly shaped by I(h) in PC dendrites, which determines the effective integration time window for inhibitory and excitatory inputs. We propose a key disynaptic mechanism by which brief bursts generated by a few PCs can synchronize the activity in the pyramidal network.
format	article
author	Thomas K Berger Gilad Silberberg Rodrigo Perin Henry Markram
author_facet	Thomas K Berger Gilad Silberberg Rodrigo Perin Henry Markram
author_sort	Thomas K Berger
title	Brief bursts self-inhibit and correlate the pyramidal network.
title_short	Brief bursts self-inhibit and correlate the pyramidal network.
title_full	Brief bursts self-inhibit and correlate the pyramidal network.
title_fullStr	Brief bursts self-inhibit and correlate the pyramidal network.
title_full_unstemmed	Brief bursts self-inhibit and correlate the pyramidal network.
title_sort	brief bursts self-inhibit and correlate the pyramidal network.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/398da57b31c3496c8b14e6fe046a0b9f
work_keys_str_mv	AT thomaskberger briefburstsselfinhibitandcorrelatethepyramidalnetwork AT giladsilberberg briefburstsselfinhibitandcorrelatethepyramidalnetwork AT rodrigoperin briefburstsselfinhibitandcorrelatethepyramidalnetwork AT henrymarkram briefburstsselfinhibitandcorrelatethepyramidalnetwork
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Brief bursts self-inhibit and correlate the pyramidal network.

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