Influence of survival, promotion, and growth on pattern formation in zebrafish skin

Abstract The coloring of zebrafish skin is often used as a model system to study biological pattern formation. However, the small number and lack of movement of chromatophores defies traditional Turing-type pattern generating mechanisms. Recent models invoke discrete short-range competition and long...

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Autores principales:	Christopher Konow, Ziyao Li, Samantha Shepherd, Domenico Bullara, Irving R. Epstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39918f4a97ed4ec6be2e6c9448e95792
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spelling	oai:doaj.org-article:39918f4a97ed4ec6be2e6c9448e957922021-12-02T14:35:34ZInfluence of survival, promotion, and growth on pattern formation in zebrafish skin10.1038/s41598-021-89116-42045-2322https://doaj.org/article/39918f4a97ed4ec6be2e6c9448e957922021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89116-4https://doaj.org/toc/2045-2322Abstract The coloring of zebrafish skin is often used as a model system to study biological pattern formation. However, the small number and lack of movement of chromatophores defies traditional Turing-type pattern generating mechanisms. Recent models invoke discrete short-range competition and long-range promotion between different pigment cells as an alternative to a reaction-diffusion scheme. In this work, we propose a lattice-based “Survival model,” which is inspired by recent experimental findings on the nature of long-range chromatophore interactions. The Survival model produces stationary patterns with diffuse stripes and undergoes a Turing instability. We also examine the effect that domain growth, ubiquitous in biological systems, has on the patterns in both the Survival model and an earlier “Promotion” model. In both cases, domain growth alone is capable of orienting Turing patterns above a threshold wavelength and can reorient the stripes in ablated cells, though the wavelength for which the patterns orient is much larger for the Survival model. While the Survival model is a simplified representation of the multifaceted interactions between pigment cells, it reveals complex organizational behavior and may help to guide future studies.Christopher KonowZiyao LiSamantha ShepherdDomenico BullaraIrving R. EpsteinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher Konow Ziyao Li Samantha Shepherd Domenico Bullara Irving R. Epstein Influence of survival, promotion, and growth on pattern formation in zebrafish skin
description	Abstract The coloring of zebrafish skin is often used as a model system to study biological pattern formation. However, the small number and lack of movement of chromatophores defies traditional Turing-type pattern generating mechanisms. Recent models invoke discrete short-range competition and long-range promotion between different pigment cells as an alternative to a reaction-diffusion scheme. In this work, we propose a lattice-based “Survival model,” which is inspired by recent experimental findings on the nature of long-range chromatophore interactions. The Survival model produces stationary patterns with diffuse stripes and undergoes a Turing instability. We also examine the effect that domain growth, ubiquitous in biological systems, has on the patterns in both the Survival model and an earlier “Promotion” model. In both cases, domain growth alone is capable of orienting Turing patterns above a threshold wavelength and can reorient the stripes in ablated cells, though the wavelength for which the patterns orient is much larger for the Survival model. While the Survival model is a simplified representation of the multifaceted interactions between pigment cells, it reveals complex organizational behavior and may help to guide future studies.
format	article
author	Christopher Konow Ziyao Li Samantha Shepherd Domenico Bullara Irving R. Epstein
author_facet	Christopher Konow Ziyao Li Samantha Shepherd Domenico Bullara Irving R. Epstein
author_sort	Christopher Konow
title	Influence of survival, promotion, and growth on pattern formation in zebrafish skin
title_short	Influence of survival, promotion, and growth on pattern formation in zebrafish skin
title_full	Influence of survival, promotion, and growth on pattern formation in zebrafish skin
title_fullStr	Influence of survival, promotion, and growth on pattern formation in zebrafish skin
title_full_unstemmed	Influence of survival, promotion, and growth on pattern formation in zebrafish skin
title_sort	influence of survival, promotion, and growth on pattern formation in zebrafish skin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/39918f4a97ed4ec6be2e6c9448e95792
work_keys_str_mv	AT christopherkonow influenceofsurvivalpromotionandgrowthonpatternformationinzebrafishskin AT ziyaoli influenceofsurvivalpromotionandgrowthonpatternformationinzebrafishskin AT samanthashepherd influenceofsurvivalpromotionandgrowthonpatternformationinzebrafishskin AT domenicobullara influenceofsurvivalpromotionandgrowthonpatternformationinzebrafishskin AT irvingrepstein influenceofsurvivalpromotionandgrowthonpatternformationinzebrafishskin
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Influence of survival, promotion, and growth on pattern formation in zebrafish skin

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