Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma

Introduction Histone deacetylase inhibitors (HDACIs) inhibit human osteosarcoma growth and cause apoptosis. Previously, we reported that HDACIs induce autophagy via the FOXO1 pathway. Whether there is involvement of autophagy in anti-osteosarcoma activity of HDACIs is still unknown. Material and me...

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Bibliographic Details
Main Authors: Yunjuan Bai, Yun Chen, Xiaochen Chen, Jiukun Jiang, Xiao Wang, Liping Wang, Jigang Wang, Jianbin Zhang, Liang Gao
Format: article
Language:EN
Published: Termedia Publishing House 2018
Subjects:
osteosarcoma
autophagy
foxo1
tsa
trichostatin a
forkhead box o1
mammalian target of rapamycin
Medicine
R
Online Access:https://doaj.org/article/39944e1f64e040dcb4ca6d94c51782f5
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https://doaj.org/article/39944e1f64e040dcb4ca6d94c51782f5

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