Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma

Introduction Histone deacetylase inhibitors (HDACIs) inhibit human osteosarcoma growth and cause apoptosis. Previously, we reported that HDACIs induce autophagy via the FOXO1 pathway. Whether there is involvement of autophagy in anti-osteosarcoma activity of HDACIs is still unknown. Material and me...

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Autores principales: Yunjuan Bai, Yun Chen, Xiaochen Chen, Jiukun Jiang, Xiao Wang, Liping Wang, Jigang Wang, Jianbin Zhang, Liang Gao
Formato: article
Lenguaje:EN
Publicado: Termedia Publishing House 2018
Materias:
osteosarcoma
autophagy
foxo1
tsa
trichostatin a
forkhead box o1
mammalian target of rapamycin
Medicine
R
Acceso en línea:https://doaj.org/article/39944e1f64e040dcb4ca6d94c51782f5
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