NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes

Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem...

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Autores principales:	Zhi Zhou, Hiroshi Kawabe, Atsushi Suzuki, Kaori Shinmyozu, Yumiko Saga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39954f4144a94d96ab7d987363f9af6f
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spelling	oai:doaj.org-article:39954f4144a94d96ab7d987363f9af6f2021-12-02T15:38:53ZNEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes10.1038/ncomms156622041-1723https://doaj.org/article/39954f4144a94d96ab7d987363f9af6f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15662https://doaj.org/toc/2041-1723Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem cells.Zhi ZhouHiroshi KawabeAtsushi SuzukiKaori ShinmyozuYumiko SagaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
description	Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem cells.
format	article
author	Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga
author_facet	Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga
author_sort	Zhi Zhou
title	NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
title_short	NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
title_full	NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
title_fullStr	NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
title_full_unstemmed	NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
title_sort	nedd4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/39954f4144a94d96ab7d987363f9af6f
work_keys_str_mv	AT zhizhou nedd4controlsspermatogonialstemcellhomeostasisandstressresponsebyregulatingmessengerribonucleoproteincomplexes AT hiroshikawabe nedd4controlsspermatogonialstemcellhomeostasisandstressresponsebyregulatingmessengerribonucleoproteincomplexes AT atsushisuzuki nedd4controlsspermatogonialstemcellhomeostasisandstressresponsebyregulatingmessengerribonucleoproteincomplexes AT kaorishinmyozu nedd4controlsspermatogonialstemcellhomeostasisandstressresponsebyregulatingmessengerribonucleoproteincomplexes AT yumikosaga nedd4controlsspermatogonialstemcellhomeostasisandstressresponsebyregulatingmessengerribonucleoproteincomplexes
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NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes

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