In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

Dystrophin-deficient mice are used to test corrective strategies for Duchenne muscular dystrophy, but evaluation of dystrophin expression requires collection of tissue samples from specific muscles and time points. Here, the authors generate mice in which dystrophin expression is coupled to lucifera...

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Autores principales:	Leonela Amoasii, Hui Li, Yu Zhang, Yi-Li Min, Efrain Sanchez-Ortiz, John M. Shelton, Chengzu Long, Alex A. Mireault, Samadrita Bhattacharyya, John R. McAnally, Rhonda Bassel-Duby, Eric N. Olson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3998bffcfb4f49da8616481acc9f1799
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spelling	oai:doaj.org-article:3998bffcfb4f49da8616481acc9f17992021-12-02T17:01:53ZIn vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse10.1038/s41467-019-12335-x2041-1723https://doaj.org/article/3998bffcfb4f49da8616481acc9f17992019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12335-xhttps://doaj.org/toc/2041-1723Dystrophin-deficient mice are used to test corrective strategies for Duchenne muscular dystrophy, but evaluation of dystrophin expression requires collection of tissue samples from specific muscles and time points. Here, the authors generate mice in which dystrophin expression is coupled to luciferase, and show that bioluminescence allows non-invasive monitoring of dystrophin expression following genome editing.Leonela AmoasiiHui LiYu ZhangYi-Li MinEfrain Sanchez-OrtizJohn M. SheltonChengzu LongAlex A. MireaultSamadrita BhattacharyyaJohn R. McAnallyRhonda Bassel-DubyEric N. OlsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonela Amoasii Hui Li Yu Zhang Yi-Li Min Efrain Sanchez-Ortiz John M. Shelton Chengzu Long Alex A. Mireault Samadrita Bhattacharyya John R. McAnally Rhonda Bassel-Duby Eric N. Olson In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
description	Dystrophin-deficient mice are used to test corrective strategies for Duchenne muscular dystrophy, but evaluation of dystrophin expression requires collection of tissue samples from specific muscles and time points. Here, the authors generate mice in which dystrophin expression is coupled to luciferase, and show that bioluminescence allows non-invasive monitoring of dystrophin expression following genome editing.
format	article
author	Leonela Amoasii Hui Li Yu Zhang Yi-Li Min Efrain Sanchez-Ortiz John M. Shelton Chengzu Long Alex A. Mireault Samadrita Bhattacharyya John R. McAnally Rhonda Bassel-Duby Eric N. Olson
author_facet	Leonela Amoasii Hui Li Yu Zhang Yi-Li Min Efrain Sanchez-Ortiz John M. Shelton Chengzu Long Alex A. Mireault Samadrita Bhattacharyya John R. McAnally Rhonda Bassel-Duby Eric N. Olson
author_sort	Leonela Amoasii
title	In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
title_short	In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
title_full	In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
title_fullStr	In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
title_full_unstemmed	In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
title_sort	in vivo non-invasive monitoring of dystrophin correction in a new duchenne muscular dystrophy reporter mouse
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3998bffcfb4f49da8616481acc9f1799
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In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

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