Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion

Abstract Excessive expansion of adipose tissue in obesity typically leads to overflow and accumulation of lipids in other tissues, causing fatty liver disease and atherosclerosis. The intracellular protein, phosphoprotein enriched in astrocytes (PEA)-15 has been linked to metabolic disease but its r...

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Autores principales:	Pola J. Verschoor, Fiona H. Greig, Justin J. Rochford, Giovanni Levate, Mirela Delibegovic, Dawn Thompson, Alasdair Leeson-Payne, Ruta Dekeryte, Ruth Banks, Joe W. Ramos, Graeme F. Nixon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/399fd1785e114387b438d128d6569ee9
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spelling	oai:doaj.org-article:399fd1785e114387b438d128d6569ee92021-12-02T16:36:12ZPhosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion10.1038/s41598-021-86250-x2045-2322https://doaj.org/article/399fd1785e114387b438d128d6569ee92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86250-xhttps://doaj.org/toc/2045-2322Abstract Excessive expansion of adipose tissue in obesity typically leads to overflow and accumulation of lipids in other tissues, causing fatty liver disease and atherosclerosis. The intracellular protein, phosphoprotein enriched in astrocytes (PEA)-15 has been linked to metabolic disease but its role in lipid storage has not been examined. To delineate the role of PEA-15 in adipose tissue, we placed PEA-15−/− mice on a high fat diet. These mice developed increased body weight and greater white adipose tissue expansion compared to high fat diet-fed wild type mice. This was due to increased adipocyte cell size in PEA-15−/− mice consistent with greater lipid storage capacity. Surprisingly, PEA-15−/− mice exhibited improvements in whole body insulin sensitivity, lower hepatic weight and decreased serum triglycerides indicating a protective phenotype. To determine effects on atherosclerosis, PEA-15−/− mice were crossed with the ApoE−/− mice on a high fat diet. Strikingly, these mice were protected from atherosclerosis and had less hepatic lipid accumulation despite increased adiposity. Therefore, we reveal for the first time that PEA-15 plays a novel role in regulating the expansion of adipose tissue. Decreasing PEA-15 expression increases the sequestering of lipids in adipose tissue, protecting other tissues in obesity, thereby improving metabolic health.Pola J. VerschoorFiona H. GreigJustin J. RochfordGiovanni LevateMirela DelibegovicDawn ThompsonAlasdair Leeson-PayneRuta DekeryteRuth BanksJoe W. RamosGraeme F. NixonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pola J. Verschoor Fiona H. Greig Justin J. Rochford Giovanni Levate Mirela Delibegovic Dawn Thompson Alasdair Leeson-Payne Ruta Dekeryte Ruth Banks Joe W. Ramos Graeme F. Nixon Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
description	Abstract Excessive expansion of adipose tissue in obesity typically leads to overflow and accumulation of lipids in other tissues, causing fatty liver disease and atherosclerosis. The intracellular protein, phosphoprotein enriched in astrocytes (PEA)-15 has been linked to metabolic disease but its role in lipid storage has not been examined. To delineate the role of PEA-15 in adipose tissue, we placed PEA-15−/− mice on a high fat diet. These mice developed increased body weight and greater white adipose tissue expansion compared to high fat diet-fed wild type mice. This was due to increased adipocyte cell size in PEA-15−/− mice consistent with greater lipid storage capacity. Surprisingly, PEA-15−/− mice exhibited improvements in whole body insulin sensitivity, lower hepatic weight and decreased serum triglycerides indicating a protective phenotype. To determine effects on atherosclerosis, PEA-15−/− mice were crossed with the ApoE−/− mice on a high fat diet. Strikingly, these mice were protected from atherosclerosis and had less hepatic lipid accumulation despite increased adiposity. Therefore, we reveal for the first time that PEA-15 plays a novel role in regulating the expansion of adipose tissue. Decreasing PEA-15 expression increases the sequestering of lipids in adipose tissue, protecting other tissues in obesity, thereby improving metabolic health.
format	article
author	Pola J. Verschoor Fiona H. Greig Justin J. Rochford Giovanni Levate Mirela Delibegovic Dawn Thompson Alasdair Leeson-Payne Ruta Dekeryte Ruth Banks Joe W. Ramos Graeme F. Nixon
author_facet	Pola J. Verschoor Fiona H. Greig Justin J. Rochford Giovanni Levate Mirela Delibegovic Dawn Thompson Alasdair Leeson-Payne Ruta Dekeryte Ruth Banks Joe W. Ramos Graeme F. Nixon
author_sort	Pola J. Verschoor
title	Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
title_short	Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
title_full	Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
title_fullStr	Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
title_full_unstemmed	Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
title_sort	phosphoprotein enriched in astrocytes (pea)-15 is a novel regulator of adipose tissue expansion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/399fd1785e114387b438d128d6569ee9
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Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion

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