Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation

ABSTRACT The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein...

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Autor principal:	J. Andrew Alspaugh
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/39a9f06127b140a69aaa55c8cb2ecfd6
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spelling	oai:doaj.org-article:39a9f06127b140a69aaa55c8cb2ecfd62021-11-15T15:49:40ZUnveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation10.1128/mBio.00021-162150-7511https://doaj.org/article/39a9f06127b140a69aaa55c8cb2ecfd62016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00021-16https://doaj.org/toc/2150-7511ABSTRACT The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase A (PKA) activation and repression in the opportunistic human fungal pathogen Cryptococcus neoformans. They observed an association between microbial PKA signaling and ubiquitin-proteasome regulation of protein homeostasis. Additionally, they correlated these processes with expression of polysaccharide capsule on the fungal cell surface, the main virulence-associated phenotype in this organism. Not only are their findings important for microbial pathogenesis, but they also support similar associations between human PKA signaling and ubiquitinated protein accumulation in neurodegenerative diseases.J. Andrew AlspaughAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 J. Andrew Alspaugh Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
description	ABSTRACT The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase A (PKA) activation and repression in the opportunistic human fungal pathogen Cryptococcus neoformans. They observed an association between microbial PKA signaling and ubiquitin-proteasome regulation of protein homeostasis. Additionally, they correlated these processes with expression of polysaccharide capsule on the fungal cell surface, the main virulence-associated phenotype in this organism. Not only are their findings important for microbial pathogenesis, but they also support similar associations between human PKA signaling and ubiquitinated protein accumulation in neurodegenerative diseases.
format	article
author	J. Andrew Alspaugh
author_facet	J. Andrew Alspaugh
author_sort	J. Andrew Alspaugh
title	Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
title_short	Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
title_full	Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
title_fullStr	Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
title_full_unstemmed	Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation
title_sort	unveiling protein kinase a targets in <named-content content-type="genus-species">cryptococcus neoformans</named-content> capsule formation
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/39a9f06127b140a69aaa55c8cb2ecfd6
work_keys_str_mv	AT jandrewalspaugh unveilingproteinkinaseatargetsinnamedcontentcontenttypegenusspeciescryptococcusneoformansnamedcontentcapsuleformation
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Unveiling Protein Kinase A Targets in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Capsule Formation

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