Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis

Accumulating evidence has suggested a shared pathophysiology between Alzheimer’s disease (AD) and cardiovascular disease (CVD). Based on genome-wide transcriptomes, specifically those of blood samples, we identify the shared disease-related signatures between AD and CVD. In addition to gene expressi...

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Autores principales:	Taesic Lee, Hyunju Lee, the Alzheimer’s Disease Neuroimaging Initiative
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease cardiovascular disease blood gene expression disease-related molecular signatures differential expression analysis gene regulatory network Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/39abeddc999b424f95de2a644bc70295
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spelling	oai:doaj.org-article:39abeddc999b424f95de2a644bc702952021-11-25T16:48:34ZIdentification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis10.3390/biomedicines91115252227-9059https://doaj.org/article/39abeddc999b424f95de2a644bc702952021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1525https://doaj.org/toc/2227-9059Accumulating evidence has suggested a shared pathophysiology between Alzheimer’s disease (AD) and cardiovascular disease (CVD). Based on genome-wide transcriptomes, specifically those of blood samples, we identify the shared disease-related signatures between AD and CVD. In addition to gene expressions in blood, the following prior knowledge were utilized to identify several candidate disease-related gene (DRG) sets: protein–protein interactions, transcription factors, disease–gene relationship databases, and single nucleotide polymorphisms. We selected the respective DRG sets for AD and CVD that show a high accuracy for disease prediction in bulk and single-cell gene expression datasets. Then, gene regulatory networks (GRNs) were constructed from each of the AD and CVD DRG sets to identify the upstream regulating genes. Using the GRNs, we identified two common upstream genes (GPBP1 and SETDB2) between the AD and CVD GRNs. In summary, this study has identified the potential AD- and CVD-related genes and common hub genes between these sets, which may help to elucidate the shared mechanisms between these two diseases.Taesic LeeHyunju Leethe Alzheimer’s Disease Neuroimaging InitiativeMDPI AGarticleAlzheimer’s diseasecardiovascular diseaseblood gene expressiondisease-related molecular signaturesdifferential expression analysisgene regulatory networkBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1525, p 1525 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease cardiovascular disease blood gene expression disease-related molecular signatures differential expression analysis gene regulatory network Biology (General) QH301-705.5
spellingShingle	Alzheimer’s disease cardiovascular disease blood gene expression disease-related molecular signatures differential expression analysis gene regulatory network Biology (General) QH301-705.5 Taesic Lee Hyunju Lee the Alzheimer’s Disease Neuroimaging Initiative Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
description	Accumulating evidence has suggested a shared pathophysiology between Alzheimer’s disease (AD) and cardiovascular disease (CVD). Based on genome-wide transcriptomes, specifically those of blood samples, we identify the shared disease-related signatures between AD and CVD. In addition to gene expressions in blood, the following prior knowledge were utilized to identify several candidate disease-related gene (DRG) sets: protein–protein interactions, transcription factors, disease–gene relationship databases, and single nucleotide polymorphisms. We selected the respective DRG sets for AD and CVD that show a high accuracy for disease prediction in bulk and single-cell gene expression datasets. Then, gene regulatory networks (GRNs) were constructed from each of the AD and CVD DRG sets to identify the upstream regulating genes. Using the GRNs, we identified two common upstream genes (GPBP1 and SETDB2) between the AD and CVD GRNs. In summary, this study has identified the potential AD- and CVD-related genes and common hub genes between these sets, which may help to elucidate the shared mechanisms between these two diseases.
format	article
author	Taesic Lee Hyunju Lee the Alzheimer’s Disease Neuroimaging Initiative
author_facet	Taesic Lee Hyunju Lee the Alzheimer’s Disease Neuroimaging Initiative
author_sort	Taesic Lee
title	Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
title_short	Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
title_full	Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
title_fullStr	Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
title_full_unstemmed	Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis
title_sort	identification of disease-related genes that are common between alzheimer’s and cardiovascular disease using blood genome-wide transcriptome analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39abeddc999b424f95de2a644bc70295
work_keys_str_mv	AT taesiclee identificationofdiseaserelatedgenesthatarecommonbetweenalzheimersandcardiovasculardiseaseusingbloodgenomewidetranscriptomeanalysis AT hyunjulee identificationofdiseaserelatedgenesthatarecommonbetweenalzheimersandcardiovasculardiseaseusingbloodgenomewidetranscriptomeanalysis AT thealzheimersdiseaseneuroimaginginitiative identificationofdiseaserelatedgenesthatarecommonbetweenalzheimersandcardiovasculardiseaseusingbloodgenomewidetranscriptomeanalysis
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Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis

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