Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity

Abstract. Ahaddin AY, Budiarti S, Mustopa AZ, Darusman HS, Triratna L. 2021. Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity. Biodiversitas 22: 227-232. Lactobacillus plantarum S34 belongs to the Lactobacilli class produces a b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arido Yugovelman Ahaddin, Sri Budiarti, Apon Zaenal Mustopa, Huda S Darusman, Lita Triratna
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	antibiotics, bacteriocin, lactobacillus plantarum, plantaricin, toxicity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/39ad1356a63a4081adcee18101443482
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39ad1356a63a4081adcee18101443482
record_format	dspace
spelling	oai:doaj.org-article:39ad1356a63a4081adcee181014434822021-11-22T00:53:57ZShort Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity1412-033X2085-472210.13057/biodiv/d220128https://doaj.org/article/39ad1356a63a4081adcee181014434822020-12-01T00:00:00Zhttps://smujo.id/biodiv/article/view/6083https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Ahaddin AY, Budiarti S, Mustopa AZ, Darusman HS, Triratna L. 2021. Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity. Biodiversitas 22: 227-232. Lactobacillus plantarum S34 belongs to the Lactobacilli class produces a bacteriocin called plantaricin. Bacteriocins are well known as active compounds that inhibit bacterial growth. This study was conducted to determine the antimicrobial activity of plantaricin S34 and its safety profile in the ddY mouse animal models. Plantaricin 34 from the crude extract was identified using Tricine SDS-PAGE. Antimicrobial activity was observed using disk diffusion against EPEC K1.1, S. aureus, S. typhosa, S typhimurium, and Proteus sp. The safety assessment showed that crude extract of plantaricin S34 did not cause any abnormalities to experimental mice even after being administrated with 5000 mg/kg BB. The identification of plantaricin S34 showed an active molecule at 7.34 kDa and had an activity to inhibit the pathogens used in this study. The blood analysis showed that the hematological and biochemical blood properties were in the normal range. Histopathological examination showed no damage to the intestine, liver, and kidneys. Thus, the crude extract of plantaricin S34 is active as an antimicrobial agent without any toxicity effects.Arido Yugovelman AhaddinSri BudiartiApon Zaenal MustopaHuda S DarusmanLita TriratnaMBI & UNS Soloarticleantibiotics, bacteriocin, lactobacillus plantarum, plantaricin, toxicityBiology (General)QH301-705.5ENBiodiversitas, Vol 22, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotics, bacteriocin, lactobacillus plantarum, plantaricin, toxicity Biology (General) QH301-705.5
spellingShingle	antibiotics, bacteriocin, lactobacillus plantarum, plantaricin, toxicity Biology (General) QH301-705.5 Arido Yugovelman Ahaddin Sri Budiarti Apon Zaenal Mustopa Huda S Darusman Lita Triratna Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
description	Abstract. Ahaddin AY, Budiarti S, Mustopa AZ, Darusman HS, Triratna L. 2021. Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity. Biodiversitas 22: 227-232. Lactobacillus plantarum S34 belongs to the Lactobacilli class produces a bacteriocin called plantaricin. Bacteriocins are well known as active compounds that inhibit bacterial growth. This study was conducted to determine the antimicrobial activity of plantaricin S34 and its safety profile in the ddY mouse animal models. Plantaricin 34 from the crude extract was identified using Tricine SDS-PAGE. Antimicrobial activity was observed using disk diffusion against EPEC K1.1, S. aureus, S. typhosa, S typhimurium, and Proteus sp. The safety assessment showed that crude extract of plantaricin S34 did not cause any abnormalities to experimental mice even after being administrated with 5000 mg/kg BB. The identification of plantaricin S34 showed an active molecule at 7.34 kDa and had an activity to inhibit the pathogens used in this study. The blood analysis showed that the hematological and biochemical blood properties were in the normal range. Histopathological examination showed no damage to the intestine, liver, and kidneys. Thus, the crude extract of plantaricin S34 is active as an antimicrobial agent without any toxicity effects.
format	article
author	Arido Yugovelman Ahaddin Sri Budiarti Apon Zaenal Mustopa Huda S Darusman Lita Triratna
author_facet	Arido Yugovelman Ahaddin Sri Budiarti Apon Zaenal Mustopa Huda S Darusman Lita Triratna
author_sort	Arido Yugovelman Ahaddin
title	Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
title_short	Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
title_full	Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
title_fullStr	Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
title_full_unstemmed	Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity
title_sort	short communication: acute toxicity study of plantaricin from lactobacillus plantarum s34 and its antibacterial activity
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/39ad1356a63a4081adcee18101443482
work_keys_str_mv	AT aridoyugovelmanahaddin shortcommunicationacutetoxicitystudyofplantaricinfromlactobacillusplantarums34anditsantibacterialactivity AT sribudiarti shortcommunicationacutetoxicitystudyofplantaricinfromlactobacillusplantarums34anditsantibacterialactivity AT aponzaenalmustopa shortcommunicationacutetoxicitystudyofplantaricinfromlactobacillusplantarums34anditsantibacterialactivity AT hudasdarusman shortcommunicationacutetoxicitystudyofplantaricinfromlactobacillusplantarums34anditsantibacterialactivity AT litatriratna shortcommunicationacutetoxicitystudyofplantaricinfromlactobacillusplantarums34anditsantibacterialactivity
_version_	1718418451641401344

Short Communication: Acute toxicity study of plantaricin from Lactobacillus plantarum S34 and its antibacterial activity

Ejemplares similares