Penile secondary lesions: a rare entity detected by PET/CT

Abstract While penile metastases are rare, PET/CT has facilitated their detection. We aimed to describe penile secondary lesions (PSL) identified by PET/CT. We reviewed 18F-FDG and Ga68-PSMA PET/CT records performed in a single center during May 2012-March 2020, for PSL. Of 16,774 18F-FDG and 1,963...

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Autores principales:	Tima Davidson, Liran Domachevsky, Yogev Giladi, Eddie Fridman, Zohar Dotan, Barak Rosenzweig, Raya Leibowitz, Jennifer Ben Shimol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39ad89284df343d4af156792a323198c
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spelling	oai:doaj.org-article:39ad89284df343d4af156792a323198c2021-12-02T17:05:00ZPenile secondary lesions: a rare entity detected by PET/CT10.1038/s41598-021-85300-82045-2322https://doaj.org/article/39ad89284df343d4af156792a323198c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85300-8https://doaj.org/toc/2045-2322Abstract While penile metastases are rare, PET/CT has facilitated their detection. We aimed to describe penile secondary lesions (PSL) identified by PET/CT. We reviewed 18F-FDG and Ga68-PSMA PET/CT records performed in a single center during May 2012-March 2020, for PSL. Of 16,774 18F-FDG and 1,963 Ga68-PSMA-PET scans, PSL were found in 24(0.13%) men with a mean age of 74. PSMA detected PSL in 12 with prostate cancer; FDG identified PSL in 4 with lymphoma, 3 with colorectal cancer, 2 with lung cancer, and one each with bladder cancer, pelvic sarcoma, and leukemia. Mean SUVmax of PSL was 7.9 ± 4.2 with focal uptake in 13(54%). Mean lesion size was 16.5 ± 6.8 mm; 8 at the penile root, 4 along the shaft, and 1 at the glans. CT detected loss of the penile texture in 15(63%). PSL were observed only during relapse or follow-up of disseminated disease. Among those with prostate cancer, PSA varied widely. Fifteen (62.5%) died, at a mean 13.3 ± 15.9 months following PSL demonstration, nine had non-prostate malignancies. PET/CT identified and characterized PSL in a fraction of cancer patients, most commonly those with prostate cancer. PSL universally surfaced in advanced disease, and signaled high mortality, especially in non-prostate cancers.Tima DavidsonLiran DomachevskyYogev GiladiEddie FridmanZohar DotanBarak RosenzweigRaya LeibowitzJennifer Ben ShimolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tima Davidson Liran Domachevsky Yogev Giladi Eddie Fridman Zohar Dotan Barak Rosenzweig Raya Leibowitz Jennifer Ben Shimol Penile secondary lesions: a rare entity detected by PET/CT
description	Abstract While penile metastases are rare, PET/CT has facilitated their detection. We aimed to describe penile secondary lesions (PSL) identified by PET/CT. We reviewed 18F-FDG and Ga68-PSMA PET/CT records performed in a single center during May 2012-March 2020, for PSL. Of 16,774 18F-FDG and 1,963 Ga68-PSMA-PET scans, PSL were found in 24(0.13%) men with a mean age of 74. PSMA detected PSL in 12 with prostate cancer; FDG identified PSL in 4 with lymphoma, 3 with colorectal cancer, 2 with lung cancer, and one each with bladder cancer, pelvic sarcoma, and leukemia. Mean SUVmax of PSL was 7.9 ± 4.2 with focal uptake in 13(54%). Mean lesion size was 16.5 ± 6.8 mm; 8 at the penile root, 4 along the shaft, and 1 at the glans. CT detected loss of the penile texture in 15(63%). PSL were observed only during relapse or follow-up of disseminated disease. Among those with prostate cancer, PSA varied widely. Fifteen (62.5%) died, at a mean 13.3 ± 15.9 months following PSL demonstration, nine had non-prostate malignancies. PET/CT identified and characterized PSL in a fraction of cancer patients, most commonly those with prostate cancer. PSL universally surfaced in advanced disease, and signaled high mortality, especially in non-prostate cancers.
format	article
author	Tima Davidson Liran Domachevsky Yogev Giladi Eddie Fridman Zohar Dotan Barak Rosenzweig Raya Leibowitz Jennifer Ben Shimol
author_facet	Tima Davidson Liran Domachevsky Yogev Giladi Eddie Fridman Zohar Dotan Barak Rosenzweig Raya Leibowitz Jennifer Ben Shimol
author_sort	Tima Davidson
title	Penile secondary lesions: a rare entity detected by PET/CT
title_short	Penile secondary lesions: a rare entity detected by PET/CT
title_full	Penile secondary lesions: a rare entity detected by PET/CT
title_fullStr	Penile secondary lesions: a rare entity detected by PET/CT
title_full_unstemmed	Penile secondary lesions: a rare entity detected by PET/CT
title_sort	penile secondary lesions: a rare entity detected by pet/ct
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/39ad89284df343d4af156792a323198c
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Penile secondary lesions: a rare entity detected by PET/CT

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