Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

Abstract Obesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance. Neuronal mitochondrial dysfunction induced by oxidative stress is an important mechanism underlying cognitive decline. Olive leaf extract contains...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Toshio Mikami, Jimmy Kim, Jonghyuk Park, Hyowon Lee, Pongson Yaicharoen, Sofya Suidasari, Miki Yokozawa, Ken Yamauchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39adaa06e18140ed9ab63c223a596812
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39adaa06e18140ed9ab63c223a596812
record_format	dspace
spelling	oai:doaj.org-article:39adaa06e18140ed9ab63c223a5968122021-12-02T17:23:16ZOlive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice10.1038/s41598-021-90589-62045-2322https://doaj.org/article/39adaa06e18140ed9ab63c223a5968122021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90589-6https://doaj.org/toc/2045-2322Abstract Obesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance. Neuronal mitochondrial dysfunction induced by oxidative stress is an important mechanism underlying cognitive decline. Olive leaf extract contains large amounts of oleanolic acid, a transmembrane G protein-coupled receptor 5 (TGR5) agonist, and oleuropein, an antioxidant. Activation of TGR5 results in enhanced mitochondrial biogenesis, which suggests that olive leaf extract may help prevent cognitive decline through its mitochondrial and antioxidant effects. Therefore, we investigated olive leaf extract’s effects on obesity, cognitive decline, depression, and endurance exercise capacity in a mouse model. In physically inactive mice fed a high-fat diet, olive leaf extract administration suppressed increases in fat mass and body weight and prevented cognitive declines, specifically decreased working memory and depressive behaviors. Additionally, olive leaf extract increased endurance exercise capacity under atmospheric and hypoxic conditions. Our study suggests that these promising effects may be related to oleanolic acid’s improvement of mitochondrial function and oleuropein’s increase of antioxidant capacity.Toshio MikamiJimmy KimJonghyuk ParkHyowon LeePongson YaicharoenSofya SuidasariMiki YokozawaKen YamauchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshio Mikami Jimmy Kim Jonghyuk Park Hyowon Lee Pongson Yaicharoen Sofya Suidasari Miki Yokozawa Ken Yamauchi Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
description	Abstract Obesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance. Neuronal mitochondrial dysfunction induced by oxidative stress is an important mechanism underlying cognitive decline. Olive leaf extract contains large amounts of oleanolic acid, a transmembrane G protein-coupled receptor 5 (TGR5) agonist, and oleuropein, an antioxidant. Activation of TGR5 results in enhanced mitochondrial biogenesis, which suggests that olive leaf extract may help prevent cognitive decline through its mitochondrial and antioxidant effects. Therefore, we investigated olive leaf extract’s effects on obesity, cognitive decline, depression, and endurance exercise capacity in a mouse model. In physically inactive mice fed a high-fat diet, olive leaf extract administration suppressed increases in fat mass and body weight and prevented cognitive declines, specifically decreased working memory and depressive behaviors. Additionally, olive leaf extract increased endurance exercise capacity under atmospheric and hypoxic conditions. Our study suggests that these promising effects may be related to oleanolic acid’s improvement of mitochondrial function and oleuropein’s increase of antioxidant capacity.
format	article
author	Toshio Mikami Jimmy Kim Jonghyuk Park Hyowon Lee Pongson Yaicharoen Sofya Suidasari Miki Yokozawa Ken Yamauchi
author_facet	Toshio Mikami Jimmy Kim Jonghyuk Park Hyowon Lee Pongson Yaicharoen Sofya Suidasari Miki Yokozawa Ken Yamauchi
author_sort	Toshio Mikami
title	Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
title_short	Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
title_full	Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
title_fullStr	Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
title_full_unstemmed	Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
title_sort	olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/39adaa06e18140ed9ab63c223a596812
work_keys_str_mv	AT toshiomikami oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT jimmykim oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT jonghyukpark oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT hyowonlee oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT pongsonyaicharoen oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT sofyasuidasari oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT mikiyokozawa oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice AT kenyamauchi oliveleafextractpreventsobesitycognitivedeclineanddepressionandimprovesexercisecapacityinmice
_version_	1718380961837613056

Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

Ejemplares similares