Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats

Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats

Christiano Bertoldo Urtado1,2, Guilherme Borges Pereira3, Marilia Bertoldo Urtado4, Érica Blascovi de Carvalho2, Gerson dos Santos Leite1, Felipe Fedrizzi Donatto1, Claudio de Oliveira Assumpção1, Richard Diego Leite3, Carlos Alberto da Silva1, Marcelo Ma...

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Autores principales: Urtado CB, Pereira GB, Urtado MB, Carvalho EB, Leite GS, Donatto FF, Assumpção CO, Leite RD, Silva CA, Sales MM, Tibana RA, Alves SCC, Prestes J
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Publicado: Dove Medical Press 2011
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Specialties of internal medicine
RC581-951
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spelling oai:doaj.org-article:39b003a659f84ccd902586d69eed896a2021-12-02T01:24:47ZResistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats1178-7007https://doaj.org/article/39b003a659f84ccd902586d69eed896a2011-11-01T00:00:00Zhttp://www.dovepress.com/resistance-training-associated-with-the-administration-of-anabolic-and-a8712https://doaj.org/toc/1178-7007Christiano Bertoldo Urtado1,2, Guilherme Borges Pereira3, Marilia Bertoldo Urtado4, Érica Blascovi de Carvalho2, Gerson dos Santos Leite1, Felipe Fedrizzi Donatto1, Claudio de Oliveira Assumpção1, Richard Diego Leite3, Carlos Alberto da Silva1, Marcelo Magalhães de Sales5, Ramires Alsamir Tibana5, Silvia Cristina Crepaldi Alves1, Jonato Prestes51Health Sciences, Methodist University of Piracicaba, Piracicaba, SP, 2Center for Investigation in Pediatrics, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, 3Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, 4Laboratory of Orofacial Pain, Division of Oral Physiology, Piracicaba Dental School, State University of Campinas, Campinas, SP, 5Graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, DF, BrazilAbstract: The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT) on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group): (1) sedentary (Sed-Intact); (2) sedentary ovariectomized (Sed-Ovx); (3) sedentary nandrolone (Sed-Intact-ND); (4) sedentary ovariectomized plus nandrolone (Sed-Ovx-ND); (5) trained (TR-Intact); (6) trained nandrolone (TR-Intact-ND); (7) trained ovariectomized (TR-Ovx); (8) trained ovariectomized plus nandrolone; (9) trained sham; and (10) trained ovariectomized plus sham. Four sessions of RT were used, during which the animals climbed a 1.1 m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with between four and nine climbs and with eight to twelve dynamic movements per climb. To test the sensitivity of insulin in the pancreas, glucose and insulin tolerance tests were performed. For insulin sensitivity, there was a statistically significant interaction for the TR-Ovx group, which presented higher sensitivity than the Sed-Intact, Sed-Ovx, and TR-Intact groups. Sed-Intact-ND and TR-Intact-ND groups exhibited higher values of insulin sensitivity than the Sed-Intact group. Except for the TR-Intact group, sensitivity was greater in trained groups than in the Sed-Intact group. There was higher insulin sensitivity in the TR-Intact-ND group than in the Sed-Intact and Sed-Intact-ND groups (P < 0.05). In conclusion, ovariectomy and short-term RT alone induced no change on insulin action. Administration of nandrolone decanoate improved insulin action, mainly when it was associated with RT.Keywords: ovariectomy, glucose, pancreas, nandrolone decanoateUrtado CBPereira GBUrtado MBCarvalho EBLeite GSDonatto FFAssumpção COLeite RDSilva CASales MMTibana RAAlves SCCPrestes JDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 385-391 (2011)
institution DOAJ
collection DOAJ
language EN
topic Specialties of internal medicine
RC581-951
spellingShingle Specialties of internal medicine
RC581-951
Urtado CB
Pereira GB
Urtado MB
Carvalho EB
Leite GS
Donatto FF
Assumpção CO
Leite RD
Silva CA
Sales MM
Tibana RA
Alves SCC
Prestes J
Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
description Christiano Bertoldo Urtado1,2, Guilherme Borges Pereira3, Marilia Bertoldo Urtado4, Érica Blascovi de Carvalho2, Gerson dos Santos Leite1, Felipe Fedrizzi Donatto1, Claudio de Oliveira Assumpção1, Richard Diego Leite3, Carlos Alberto da Silva1, Marcelo Magalhães de Sales5, Ramires Alsamir Tibana5, Silvia Cristina Crepaldi Alves1, Jonato Prestes51Health Sciences, Methodist University of Piracicaba, Piracicaba, SP, 2Center for Investigation in Pediatrics, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, 3Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, 4Laboratory of Orofacial Pain, Division of Oral Physiology, Piracicaba Dental School, State University of Campinas, Campinas, SP, 5Graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, DF, BrazilAbstract: The aim of the present study was to investigate the effects of anabolic-androgenic steroids and resistance training (RT) on insulin sensitivity in ovariectomized rats. Adult female Wistar rats were divided into ten experimental groups (n = 5 animals per group): (1) sedentary (Sed-Intact); (2) sedentary ovariectomized (Sed-Ovx); (3) sedentary nandrolone (Sed-Intact-ND); (4) sedentary ovariectomized plus nandrolone (Sed-Ovx-ND); (5) trained (TR-Intact); (6) trained nandrolone (TR-Intact-ND); (7) trained ovariectomized (TR-Ovx); (8) trained ovariectomized plus nandrolone; (9) trained sham; and (10) trained ovariectomized plus sham. Four sessions of RT were used, during which the animals climbed a 1.1 m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with between four and nine climbs and with eight to twelve dynamic movements per climb. To test the sensitivity of insulin in the pancreas, glucose and insulin tolerance tests were performed. For insulin sensitivity, there was a statistically significant interaction for the TR-Ovx group, which presented higher sensitivity than the Sed-Intact, Sed-Ovx, and TR-Intact groups. Sed-Intact-ND and TR-Intact-ND groups exhibited higher values of insulin sensitivity than the Sed-Intact group. Except for the TR-Intact group, sensitivity was greater in trained groups than in the Sed-Intact group. There was higher insulin sensitivity in the TR-Intact-ND group than in the Sed-Intact and Sed-Intact-ND groups (P < 0.05). In conclusion, ovariectomy and short-term RT alone induced no change on insulin action. Administration of nandrolone decanoate improved insulin action, mainly when it was associated with RT.Keywords: ovariectomy, glucose, pancreas, nandrolone decanoate
format article
author Urtado CB
Pereira GB
Urtado MB
Carvalho EB
Leite GS
Donatto FF
Assumpção CO
Leite RD
Silva CA
Sales MM
Tibana RA
Alves SCC
Prestes J
author_facet Urtado CB
Pereira GB
Urtado MB
Carvalho EB
Leite GS
Donatto FF
Assumpção CO
Leite RD
Silva CA
Sales MM
Tibana RA
Alves SCC
Prestes J
author_sort Urtado CB
title Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
title_short Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
title_full Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
title_fullStr Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
title_full_unstemmed Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
title_sort resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/39b003a659f84ccd902586d69eed896a
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