Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted...
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MDPI AG
2021
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oai:doaj.org-article:39b0ee406efd419bb9d400f11a4b433d2021-11-25T16:23:21ZSelf-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin10.3390/antibiotics101113512079-6382https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1351https://doaj.org/toc/2079-6382The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.Micaela Machado QueridoIvo PauloSriram HariharakrishnanDaniel RochaNuno BarbosaRui Galhano dos SantosJoão Moura BordadoJoão Paulo TeixeiraCristiana Costa PereiraMDPI AGarticlecolophonycurcuminpaintantimicrobialself-disinfectingcytotoxicityTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1351, p 1351 (2021) |
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colophony curcumin paint antimicrobial self-disinfecting cytotoxicity Therapeutics. Pharmacology RM1-950 |
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colophony curcumin paint antimicrobial self-disinfecting cytotoxicity Therapeutics. Pharmacology RM1-950 Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
description |
The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used. |
format |
article |
author |
Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira |
author_facet |
Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira |
author_sort |
Micaela Machado Querido |
title |
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
title_short |
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
title_full |
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
title_fullStr |
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
title_full_unstemmed |
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin |
title_sort |
self-disinfecting paints with the natural antimicrobial substances: colophony and curcumin |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d |
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