Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted...

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Autores principales:	Micaela Machado Querido, Ivo Paulo, Sriram Hariharakrishnan, Daniel Rocha, Nuno Barbosa, Rui Galhano dos Santos, João Moura Bordado, João Paulo Teixeira, Cristiana Costa Pereira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colophony curcumin paint antimicrobial self-disinfecting cytotoxicity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d
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spelling	oai:doaj.org-article:39b0ee406efd419bb9d400f11a4b433d2021-11-25T16:23:21ZSelf-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin10.3390/antibiotics101113512079-6382https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1351https://doaj.org/toc/2079-6382The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.Micaela Machado QueridoIvo PauloSriram HariharakrishnanDaniel RochaNuno BarbosaRui Galhano dos SantosJoão Moura BordadoJoão Paulo TeixeiraCristiana Costa PereiraMDPI AGarticlecolophonycurcuminpaintantimicrobialself-disinfectingcytotoxicityTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1351, p 1351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colophony curcumin paint antimicrobial self-disinfecting cytotoxicity Therapeutics. Pharmacology RM1-950
spellingShingle	colophony curcumin paint antimicrobial self-disinfecting cytotoxicity Therapeutics. Pharmacology RM1-950 Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
description	The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.
format	article
author	Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira
author_facet	Micaela Machado Querido Ivo Paulo Sriram Hariharakrishnan Daniel Rocha Nuno Barbosa Rui Galhano dos Santos João Moura Bordado João Paulo Teixeira Cristiana Costa Pereira
author_sort	Micaela Machado Querido
title	Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_short	Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full	Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_fullStr	Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full_unstemmed	Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_sort	self-disinfecting paints with the natural antimicrobial substances: colophony and curcumin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d
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Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

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