Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted...

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Autores principales: Micaela Machado Querido, Ivo Paulo, Sriram Hariharakrishnan, Daniel Rocha, Nuno Barbosa, Rui Galhano dos Santos, João Moura Bordado, João Paulo Teixeira, Cristiana Costa Pereira
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d
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spelling oai:doaj.org-article:39b0ee406efd419bb9d400f11a4b433d2021-11-25T16:23:21ZSelf-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin10.3390/antibiotics101113512079-6382https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1351https://doaj.org/toc/2079-6382The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.Micaela Machado QueridoIvo PauloSriram HariharakrishnanDaniel RochaNuno BarbosaRui Galhano dos SantosJoão Moura BordadoJoão Paulo TeixeiraCristiana Costa PereiraMDPI AGarticlecolophonycurcuminpaintantimicrobialself-disinfectingcytotoxicityTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1351, p 1351 (2021)
institution DOAJ
collection DOAJ
language EN
topic colophony
curcumin
paint
antimicrobial
self-disinfecting
cytotoxicity
Therapeutics. Pharmacology
RM1-950
spellingShingle colophony
curcumin
paint
antimicrobial
self-disinfecting
cytotoxicity
Therapeutics. Pharmacology
RM1-950
Micaela Machado Querido
Ivo Paulo
Sriram Hariharakrishnan
Daniel Rocha
Nuno Barbosa
Rui Galhano dos Santos
João Moura Bordado
João Paulo Teixeira
Cristiana Costa Pereira
Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
description The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Bacillus cereus</i>. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.
format article
author Micaela Machado Querido
Ivo Paulo
Sriram Hariharakrishnan
Daniel Rocha
Nuno Barbosa
Rui Galhano dos Santos
João Moura Bordado
João Paulo Teixeira
Cristiana Costa Pereira
author_facet Micaela Machado Querido
Ivo Paulo
Sriram Hariharakrishnan
Daniel Rocha
Nuno Barbosa
Rui Galhano dos Santos
João Moura Bordado
João Paulo Teixeira
Cristiana Costa Pereira
author_sort Micaela Machado Querido
title Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_short Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_fullStr Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full_unstemmed Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_sort self-disinfecting paints with the natural antimicrobial substances: colophony and curcumin
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/39b0ee406efd419bb9d400f11a4b433d
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