SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE

Susceptibility to 16 antimicrobial agents in 421 Klebsiella pneumoniae strains, isolated in a multidisciplinary medical centre from patients with nosocomial infections in 2015, was tested. The majority of studied strains were resistant to antibiotics: ampicillin/clavulanic acid (91.4%), ticarcillin/...

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Autores principales:	N. S. Kozlova, N. E. Barantsevich, E. P. Barantsevich
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	klebsiella pneumonia antibiotics resistance to antibiotics carbapenemases multidisciplinary medical centre nosocomial infection Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/39b0f201bc874bfe8e7725b1f307e781
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spelling	oai:doaj.org-article:39b0f201bc874bfe8e7725b1f307e7812021-11-22T07:09:49ZSUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE2220-76192313-739810.15789/2220-7619-2018-1-79-84https://doaj.org/article/39b0f201bc874bfe8e7725b1f307e7812018-05-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/676https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Susceptibility to 16 antimicrobial agents in 421 Klebsiella pneumoniae strains, isolated in a multidisciplinary medical centre from patients with nosocomial infections in 2015, was tested. The majority of studied strains were resistant to antibiotics: ampicillin/clavulanic acid (91.4%), ticarcillin/clavlanic acid (81.9%), piperacillin/tazobactam (69.4%), fluorochinolones (83.6%), III and IV generation of cephalosporines (79.8%), gentamycin (72.9%); one third (34.2%) demonstrated resistance to amikacin. K. pneumoniae strains demonstrated high level of carbapenem resistance (53.0% — to ertapenem, 42.8% — to meropenem and 37.1% — to imipenem), associated resistance to at least 3 different classes of antibiotics — caphalosporins, aminoglycozides, fluorochinolones, that amounted to more than half of the strains (57.7%), including 44.2% of the strains, additionally resistant to carbapenems. The lowest level of resistance was found to fosfomycin (8.5%) and tigecycline (7.4%), resistant cultures showed intermediate resistance with MIC 2 μg/ml to the latter. High diversity of antimicrobial resistance spectra was found, with high level of multidrug resistant strains (87.2%). Resistance to carapenems in K. pneumoniae isolated in the multidisciplinary medical center was determined by either blaOXA-48 (59.3% of isolates, resistant to carbapenems) or blaNDM-1 (40.7%).N. S. KozlovaN. E. BarantsevichE. P. BarantsevichSankt-Peterburg : NIIÈM imeni Pasteraarticleklebsiella pneumoniaantibioticsresistance to antibioticscarbapenemasesmultidisciplinary medical centrenosocomial infectionInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 1, Pp 79-84 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	klebsiella pneumonia antibiotics resistance to antibiotics carbapenemases multidisciplinary medical centre nosocomial infection Infectious and parasitic diseases RC109-216
spellingShingle	klebsiella pneumonia antibiotics resistance to antibiotics carbapenemases multidisciplinary medical centre nosocomial infection Infectious and parasitic diseases RC109-216 N. S. Kozlova N. E. Barantsevich E. P. Barantsevich SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
description	Susceptibility to 16 antimicrobial agents in 421 Klebsiella pneumoniae strains, isolated in a multidisciplinary medical centre from patients with nosocomial infections in 2015, was tested. The majority of studied strains were resistant to antibiotics: ampicillin/clavulanic acid (91.4%), ticarcillin/clavlanic acid (81.9%), piperacillin/tazobactam (69.4%), fluorochinolones (83.6%), III and IV generation of cephalosporines (79.8%), gentamycin (72.9%); one third (34.2%) demonstrated resistance to amikacin. K. pneumoniae strains demonstrated high level of carbapenem resistance (53.0% — to ertapenem, 42.8% — to meropenem and 37.1% — to imipenem), associated resistance to at least 3 different classes of antibiotics — caphalosporins, aminoglycozides, fluorochinolones, that amounted to more than half of the strains (57.7%), including 44.2% of the strains, additionally resistant to carbapenems. The lowest level of resistance was found to fosfomycin (8.5%) and tigecycline (7.4%), resistant cultures showed intermediate resistance with MIC 2 μg/ml to the latter. High diversity of antimicrobial resistance spectra was found, with high level of multidrug resistant strains (87.2%). Resistance to carapenems in K. pneumoniae isolated in the multidisciplinary medical center was determined by either blaOXA-48 (59.3% of isolates, resistant to carbapenems) or blaNDM-1 (40.7%).
format	article
author	N. S. Kozlova N. E. Barantsevich E. P. Barantsevich
author_facet	N. S. Kozlova N. E. Barantsevich E. P. Barantsevich
author_sort	N. S. Kozlova
title	SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
title_short	SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
title_full	SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
title_fullStr	SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
title_full_unstemmed	SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
title_sort	susceptibility to antibiotics in klebsiella pneumoniae strains isolated in a multidisciplinary medical centre
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/39b0f201bc874bfe8e7725b1f307e781
work_keys_str_mv	AT nskozlova susceptibilitytoantibioticsinklebsiellapneumoniaestrainsisolatedinamultidisciplinarymedicalcentre AT nebarantsevich susceptibilitytoantibioticsinklebsiellapneumoniaestrainsisolatedinamultidisciplinarymedicalcentre AT epbarantsevich susceptibilitytoantibioticsinklebsiellapneumoniaestrainsisolatedinamultidisciplinarymedicalcentre
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SUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE

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