Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report

Abstract Background Primary hepatic neuroendocrine carcinomas (NECs) are extremely rare. The rate of recurrence after resection is extremely high, and the prognosis is poor. It is debatable whether chemotherapy or surgical resection is the optimal initial treatment for primary hepatic NECs. Therefor...

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Autores principales:	Yusuke Seki, Hiroki Sakata, Toshimasa Uekusa, Hirokazu Momose, Satomi Yoneyama, Akio Hidemura, Yusuke Tajima, Hiroyuki Suzuki, Masahiro Ishimaru
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Primary hepatic neuroendocrine carcinoma Chemotherapy Surgical resection Surgery RD1-811
Acceso en línea:	https://doaj.org/article/39b224b6349a4fbc8abb3d58baeafb1f
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spelling	oai:doaj.org-article:39b224b6349a4fbc8abb3d58baeafb1f2021-11-08T11:03:41ZPrimary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report10.1186/s40792-021-01315-32198-7793https://doaj.org/article/39b224b6349a4fbc8abb3d58baeafb1f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40792-021-01315-3https://doaj.org/toc/2198-7793Abstract Background Primary hepatic neuroendocrine carcinomas (NECs) are extremely rare. The rate of recurrence after resection is extremely high, and the prognosis is poor. It is debatable whether chemotherapy or surgical resection is the optimal initial treatment for primary hepatic NECs. Therefore, selecting an appropriate therapeutic approach for patients with primary hepatic NECs remains clinically challenging. We present a case of primary hepatic NEC in a patient who developed recurrence after undergoing surgical resection. Case presentation A 78-year-old man with bone metastases of prostate cancer was referred to our department because of a solitary 66-mm tumor in the left lateral segment of the liver, which was detected on annual follow-up by computed tomography after prostate resection. A biopsy and preoperative diagnostic workup identified the lesion as a primary hepatic neuroendocrine carcinoma; therefore, left lateral segmentectomy was performed. Immunohistochemically, the tumor was positive for chromogranin A, synaptophysin, and CD 56, and the Ki-67 index was 40%. This neuroendocrine carcinoma was classified as a large cell type. Adjuvant chemotherapy with carboplatin + etoposide was initially administered a month after surgery. However, lymph node recurrence occurred 4 months after surgery, and the patient died of systemic metastases 15 months after surgical resection. Conclusions Due to the lack of availability of abundant quantities of relevant, high-quality data, there is no standard therapy for primary hepatic NECs. Selecting the most appropriate treatment for patients depending on several factors, such as the stage and differentiation of a tumor and a patient’s performance status and clinical course, is consequently preferred. More cases need to be studied to establish the best treatment strategy for primary hepatic NEC.Yusuke SekiHiroki SakataToshimasa UekusaHirokazu MomoseSatomi YoneyamaAkio HidemuraYusuke TajimaHiroyuki SuzukiMasahiro IshimaruSpringerOpenarticlePrimary hepatic neuroendocrine carcinomaChemotherapySurgical resectionSurgeryRD1-811ENSurgical Case Reports, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Primary hepatic neuroendocrine carcinoma Chemotherapy Surgical resection Surgery RD1-811
spellingShingle	Primary hepatic neuroendocrine carcinoma Chemotherapy Surgical resection Surgery RD1-811 Yusuke Seki Hiroki Sakata Toshimasa Uekusa Hirokazu Momose Satomi Yoneyama Akio Hidemura Yusuke Tajima Hiroyuki Suzuki Masahiro Ishimaru Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
description	Abstract Background Primary hepatic neuroendocrine carcinomas (NECs) are extremely rare. The rate of recurrence after resection is extremely high, and the prognosis is poor. It is debatable whether chemotherapy or surgical resection is the optimal initial treatment for primary hepatic NECs. Therefore, selecting an appropriate therapeutic approach for patients with primary hepatic NECs remains clinically challenging. We present a case of primary hepatic NEC in a patient who developed recurrence after undergoing surgical resection. Case presentation A 78-year-old man with bone metastases of prostate cancer was referred to our department because of a solitary 66-mm tumor in the left lateral segment of the liver, which was detected on annual follow-up by computed tomography after prostate resection. A biopsy and preoperative diagnostic workup identified the lesion as a primary hepatic neuroendocrine carcinoma; therefore, left lateral segmentectomy was performed. Immunohistochemically, the tumor was positive for chromogranin A, synaptophysin, and CD 56, and the Ki-67 index was 40%. This neuroendocrine carcinoma was classified as a large cell type. Adjuvant chemotherapy with carboplatin + etoposide was initially administered a month after surgery. However, lymph node recurrence occurred 4 months after surgery, and the patient died of systemic metastases 15 months after surgical resection. Conclusions Due to the lack of availability of abundant quantities of relevant, high-quality data, there is no standard therapy for primary hepatic NECs. Selecting the most appropriate treatment for patients depending on several factors, such as the stage and differentiation of a tumor and a patient’s performance status and clinical course, is consequently preferred. More cases need to be studied to establish the best treatment strategy for primary hepatic NEC.
format	article
author	Yusuke Seki Hiroki Sakata Toshimasa Uekusa Hirokazu Momose Satomi Yoneyama Akio Hidemura Yusuke Tajima Hiroyuki Suzuki Masahiro Ishimaru
author_facet	Yusuke Seki Hiroki Sakata Toshimasa Uekusa Hirokazu Momose Satomi Yoneyama Akio Hidemura Yusuke Tajima Hiroyuki Suzuki Masahiro Ishimaru
author_sort	Yusuke Seki
title	Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
title_short	Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
title_full	Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
title_fullStr	Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
title_full_unstemmed	Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
title_sort	primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/39b224b6349a4fbc8abb3d58baeafb1f
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_version_	1718442412925255680

Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report

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