Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy

Kaleab Alemayehu Zewdie,1 Muluken Altaye Ayza,1 Bekalu Amare Tesfaye,1 Ebrahim M Yimer2 1Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespon...

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Autores principales:	Zewdie KA, Ayza MA, Amare Tesfaye B, Yimer EM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic retinopathy netrin -1 netrin -4 biomarker diabetes mellitus Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/39b34537205341099a9f9113330e34db
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spelling	oai:doaj.org-article:39b34537205341099a9f9113330e34db2021-12-02T13:04:13ZTargeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy1177-5483https://doaj.org/article/39b34537205341099a9f9113330e34db2020-06-01T00:00:00Zhttps://www.dovepress.com/targeting-netrin-1-and--4-as-a-novel-diagnostic-parameter-and-treatmen-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kaleab Alemayehu Zewdie,1 Muluken Altaye Ayza,1 Bekalu Amare Tesfaye,1 Ebrahim M Yimer2 1Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespondence: Kaleab Alemayehu ZewdieDepartment of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, PO Box 1871, Mekelle, EthiopiaTel +251921546562Email kalxy2919@gmail.comAbstract: Diabetic retinopathy (DR) is a retinal vascular disorder associated with both type 1 and type 2 diabetes mellitus (DM). It is characterized by specific loss of pericytes, which leads to an augmented blood vessel permeability, and development of new blood vessels (retinal neovascularization). Moreover, stiffening of eye membrane, inflammation, and apoptosis of endothelial cells also lead to damage of the blood–retinal barrier and blindness in most cases unless it’s detected and managed early. Hence, this review was intended to assess the potential roles of Netrin-1 and -4 as new/alternative biomarkers and therapeutic options for DR. Netrin-1 and -4 have been the most known ligands and are well known for their role in neural guidance. DR has both neural and vascular components; therefore, biomarkers used for both neural and vascular retinal tissues are potentially important. According to different experimental and clinical studies, as compared to the normal groups, there was a significant increment in both retinal Netrin-1 and -4 mRNA and protein levels in the retinopathy groups. In addition, exogenous supplementation of these proteins is also used as a therapeutic agent for DR.Keywords: diabetic retinopathy, Netrin-1, Netrin-4, biomarker, diabetes mellitusZewdie KAAyza MAAmare Tesfaye BYimer EMDove Medical Pressarticlediabetic retinopathynetrin -1netrin -4biomarkerdiabetes mellitusOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1741-1747 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy netrin -1 netrin -4 biomarker diabetes mellitus Ophthalmology RE1-994
spellingShingle	diabetic retinopathy netrin -1 netrin -4 biomarker diabetes mellitus Ophthalmology RE1-994 Zewdie KA Ayza MA Amare Tesfaye B Yimer EM Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
description	Kaleab Alemayehu Zewdie,1 Muluken Altaye Ayza,1 Bekalu Amare Tesfaye,1 Ebrahim M Yimer2 1Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespondence: Kaleab Alemayehu ZewdieDepartment of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, PO Box 1871, Mekelle, EthiopiaTel +251921546562Email kalxy2919@gmail.comAbstract: Diabetic retinopathy (DR) is a retinal vascular disorder associated with both type 1 and type 2 diabetes mellitus (DM). It is characterized by specific loss of pericytes, which leads to an augmented blood vessel permeability, and development of new blood vessels (retinal neovascularization). Moreover, stiffening of eye membrane, inflammation, and apoptosis of endothelial cells also lead to damage of the blood–retinal barrier and blindness in most cases unless it’s detected and managed early. Hence, this review was intended to assess the potential roles of Netrin-1 and -4 as new/alternative biomarkers and therapeutic options for DR. Netrin-1 and -4 have been the most known ligands and are well known for their role in neural guidance. DR has both neural and vascular components; therefore, biomarkers used for both neural and vascular retinal tissues are potentially important. According to different experimental and clinical studies, as compared to the normal groups, there was a significant increment in both retinal Netrin-1 and -4 mRNA and protein levels in the retinopathy groups. In addition, exogenous supplementation of these proteins is also used as a therapeutic agent for DR.Keywords: diabetic retinopathy, Netrin-1, Netrin-4, biomarker, diabetes mellitus
format	article
author	Zewdie KA Ayza MA Amare Tesfaye B Yimer EM
author_facet	Zewdie KA Ayza MA Amare Tesfaye B Yimer EM
author_sort	Zewdie KA
title	Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
title_short	Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
title_full	Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
title_fullStr	Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
title_full_unstemmed	Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
title_sort	targeting netrin-1 and -4 as a novel diagnostic parameter and treatment option for diabetic retinopathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/39b34537205341099a9f9113330e34db
work_keys_str_mv	AT zewdieka targetingnetrin1and4asanoveldiagnosticparameterandtreatmentoptionfordiabeticretinopathy AT ayzama targetingnetrin1and4asanoveldiagnosticparameterandtreatmentoptionfordiabeticretinopathy AT amaretesfayeb targetingnetrin1and4asanoveldiagnosticparameterandtreatmentoptionfordiabeticretinopathy AT yimerem targetingnetrin1and4asanoveldiagnosticparameterandtreatmentoptionfordiabeticretinopathy
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Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy

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