The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection

Hepatitis B virus (HBV) infection is one of the serious health problems in the world as HBV causes severe liver diseases. Moreover, HBV reactivation has occasionally been observed in patients with resolved HBV infection and patients using immunosuppression and anticancer drugs. Large-scale hospital...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroyuki Amano, Tatsuo Kanda, Hitoshi Mochizuki, Yuichiro Kojima, Yoji Suzuki, Kenji Hosoda, Hiroshi Ashizawa, Yuko Miura, Shotaro Tsunoda, Yosuke Hirotsu, Hiroshi Ohyama, Naoya Kato, Mitsuhiko Moriyama, Shuntaro Obi, Masao Omata
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ACLF acute liver failure ALT elevation HBV reactivation HBV surface antigen Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/39b5397846db4ef8aef95e73fdbb60e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39b5397846db4ef8aef95e73fdbb60e9
record_format	dspace
spelling	oai:doaj.org-article:39b5397846db4ef8aef95e73fdbb60e92021-11-25T19:13:25ZThe Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection10.3390/v131122161999-4915https://doaj.org/article/39b5397846db4ef8aef95e73fdbb60e92021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2216https://doaj.org/toc/1999-4915Hepatitis B virus (HBV) infection is one of the serious health problems in the world as HBV causes severe liver diseases. Moreover, HBV reactivation has occasionally been observed in patients with resolved HBV infection and patients using immunosuppression and anticancer drugs. Large-scale hospital data focused on HBV infection and severe liver function were analyzed at our hospital, located in an urban area adjacent to Tokyo, the capital city of Japan. A total of 99,932 individuals whose blood samples were taken at 7,170,240 opportunities were analyzed. The HBV surface antigen (HBsAg)-positive group had a more frequent prevalence of patients with higher transaminase elevations than the HBsAg-negative group. However, among the HBsAg-negative group, patients who were positive for anti-HBV surface antibody and/or anti-HBV core antibody, had more severe liver conditions and fatal outcomes. More careful attention should be paid to alanine transaminase (ALT) elevations higher than 1000 IU/L in patients who had current and previous HBV infection.Hiroyuki AmanoTatsuo KandaHitoshi MochizukiYuichiro KojimaYoji SuzukiKenji HosodaHiroshi AshizawaYuko MiuraShotaro TsunodaYosuke HirotsuHiroshi OhyamaNaoya KatoMitsuhiko MoriyamaShuntaro ObiMasao OmataMDPI AGarticleACLFacute liver failureALT elevationHBV reactivationHBV surface antigenMicrobiologyQR1-502ENViruses, Vol 13, Iss 2216, p 2216 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ACLF acute liver failure ALT elevation HBV reactivation HBV surface antigen Microbiology QR1-502
spellingShingle	ACLF acute liver failure ALT elevation HBV reactivation HBV surface antigen Microbiology QR1-502 Hiroyuki Amano Tatsuo Kanda Hitoshi Mochizuki Yuichiro Kojima Yoji Suzuki Kenji Hosoda Hiroshi Ashizawa Yuko Miura Shotaro Tsunoda Yosuke Hirotsu Hiroshi Ohyama Naoya Kato Mitsuhiko Moriyama Shuntaro Obi Masao Omata The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
description	Hepatitis B virus (HBV) infection is one of the serious health problems in the world as HBV causes severe liver diseases. Moreover, HBV reactivation has occasionally been observed in patients with resolved HBV infection and patients using immunosuppression and anticancer drugs. Large-scale hospital data focused on HBV infection and severe liver function were analyzed at our hospital, located in an urban area adjacent to Tokyo, the capital city of Japan. A total of 99,932 individuals whose blood samples were taken at 7,170,240 opportunities were analyzed. The HBV surface antigen (HBsAg)-positive group had a more frequent prevalence of patients with higher transaminase elevations than the HBsAg-negative group. However, among the HBsAg-negative group, patients who were positive for anti-HBV surface antibody and/or anti-HBV core antibody, had more severe liver conditions and fatal outcomes. More careful attention should be paid to alanine transaminase (ALT) elevations higher than 1000 IU/L in patients who had current and previous HBV infection.
format	article
author	Hiroyuki Amano Tatsuo Kanda Hitoshi Mochizuki Yuichiro Kojima Yoji Suzuki Kenji Hosoda Hiroshi Ashizawa Yuko Miura Shotaro Tsunoda Yosuke Hirotsu Hiroshi Ohyama Naoya Kato Mitsuhiko Moriyama Shuntaro Obi Masao Omata
author_facet	Hiroyuki Amano Tatsuo Kanda Hitoshi Mochizuki Yuichiro Kojima Yoji Suzuki Kenji Hosoda Hiroshi Ashizawa Yuko Miura Shotaro Tsunoda Yosuke Hirotsu Hiroshi Ohyama Naoya Kato Mitsuhiko Moriyama Shuntaro Obi Masao Omata
author_sort	Hiroyuki Amano
title	The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
title_short	The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
title_full	The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
title_fullStr	The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
title_full_unstemmed	The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection
title_sort	use of electronic medical records-based big-data informatics to describe alt elevations higher than 1000 iu/l in patients with or without hepatitis b virus infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39b5397846db4ef8aef95e73fdbb60e9
work_keys_str_mv	AT hiroyukiamano theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT tatsuokanda theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hitoshimochizuki theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yuichirokojima theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yojisuzuki theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT kenjihosoda theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hiroshiashizawa theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yukomiura theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT shotarotsunoda theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yosukehirotsu theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hiroshiohyama theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT naoyakato theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT mitsuhikomoriyama theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT shuntaroobi theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT masaoomata theuseofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hiroyukiamano useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT tatsuokanda useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hitoshimochizuki useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yuichirokojima useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yojisuzuki useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT kenjihosoda useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hiroshiashizawa useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yukomiura useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT shotarotsunoda useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT yosukehirotsu useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT hiroshiohyama useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT naoyakato useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT mitsuhikomoriyama useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT shuntaroobi useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection AT masaoomata useofelectronicmedicalrecordsbasedbigdatainformaticstodescribealtelevationshigherthan1000iulinpatientswithorwithouthepatitisbvirusinfection
_version_	1718410147826499584

The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection

Ejemplares similares