Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats

In this article data on the analysis of the effect of transgenic Kalanchoe pinnate extract with cecropin P1 on the state of uninfected wounds in rats are presented. The study used Wistar rats weighing 220 ± 20 g. A wound of 20 × 20 mm was modeled under anesthesia in sterile conditions. The wound was...

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Autores principales:	Belous Alexandr, Trubnikova Elena, Kljavs Yuri
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/39b67c86154d4fe4b3aaebc31a7fc96d
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spelling	oai:doaj.org-article:39b67c86154d4fe4b3aaebc31a7fc96d2021-11-08T15:17:31ZAnalysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats2117-445810.1051/bioconf/20213700119https://doaj.org/article/39b67c86154d4fe4b3aaebc31a7fc96d2021-01-01T00:00:00Zhttps://www.bio-conferences.org/articles/bioconf/pdf/2021/09/bioconf_fies2021_00119.pdfhttps://doaj.org/toc/2117-4458In this article data on the analysis of the effect of transgenic Kalanchoe pinnate extract with cecropin P1 on the state of uninfected wounds in rats are presented. The study used Wistar rats weighing 220 ± 20 g. A wound of 20 × 20 mm was modeled under anesthesia in sterile conditions. The wound was treated during 14 days with the 3% hydrogen peroxide solution in all experimental groups. Additional treatment with the 10% cefazolin solution was used in group No. 2; with Kalanchoe juice it was used in group No. 3, and with transgenic Kalanchoe extract cecropin P1 it was used in group No. 4. The effectiveness of the treatment of the wound process was evaluated by the external state of the wound and planimetry indicators. It was found that all analyzed parameters of the experimental groups were better than in the control group of animals. However, the effect was most pronounced in the group treated by transgenic Kalanchoe extract with cecropin P1, The results of the study allow us to recommend further preclinical study of the substance for the possible treatment of trophic ulcers in patients with diabetes mellitus.Belous AlexandrTrubnikova ElenaKljavs YuriEDP SciencesarticleMicrobiologyQR1-502PhysiologyQP1-981ZoologyQL1-991ENFRBIO Web of Conferences, Vol 37, p 00119 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
spellingShingle	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991 Belous Alexandr Trubnikova Elena Kljavs Yuri Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
description	In this article data on the analysis of the effect of transgenic Kalanchoe pinnate extract with cecropin P1 on the state of uninfected wounds in rats are presented. The study used Wistar rats weighing 220 ± 20 g. A wound of 20 × 20 mm was modeled under anesthesia in sterile conditions. The wound was treated during 14 days with the 3% hydrogen peroxide solution in all experimental groups. Additional treatment with the 10% cefazolin solution was used in group No. 2; with Kalanchoe juice it was used in group No. 3, and with transgenic Kalanchoe extract cecropin P1 it was used in group No. 4. The effectiveness of the treatment of the wound process was evaluated by the external state of the wound and planimetry indicators. It was found that all analyzed parameters of the experimental groups were better than in the control group of animals. However, the effect was most pronounced in the group treated by transgenic Kalanchoe extract with cecropin P1, The results of the study allow us to recommend further preclinical study of the substance for the possible treatment of trophic ulcers in patients with diabetes mellitus.
format	article
author	Belous Alexandr Trubnikova Elena Kljavs Yuri
author_facet	Belous Alexandr Trubnikova Elena Kljavs Yuri
author_sort	Belous Alexandr
title	Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
title_short	Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
title_full	Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
title_fullStr	Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
title_full_unstemmed	Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats
title_sort	analysis of the influence of transgenic kalanchoe extract with cecropin p1 on the state of a non-infected wound in rats
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/39b67c86154d4fe4b3aaebc31a7fc96d
work_keys_str_mv	AT belousalexandr analysisoftheinfluenceoftransgenickalanchoeextractwithcecropinp1onthestateofanoninfectedwoundinrats AT trubnikovaelena analysisoftheinfluenceoftransgenickalanchoeextractwithcecropinp1onthestateofanoninfectedwoundinrats AT kljavsyuri analysisoftheinfluenceoftransgenickalanchoeextractwithcecropinp1onthestateofanoninfectedwoundinrats
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Analysis of the influence of transgenic kalanchoe extract with cecropin P1 on the state of a non-infected wound in rats

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