Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.

<h4>Background</h4>The incidence of Post-CABG atrial fibrillation (AF) lies between 25% and 40%. It worsens morbidity and raises post-operative costs. Detection of incoming AF soon enough for prophylactic intervention would be helpful. The study is to investigate the electrophysiological...

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Autores principales:	Feng Xiong, Yalin Yin, Bruno Dubé, Pierre Pagé, Alain Vinet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39bae2d52e844cd0b54cac19d6cea3d4
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spelling	oai:doaj.org-article:39bae2d52e844cd0b54cac19d6cea3d42021-11-25T05:59:42ZElectrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.1932-620310.1371/journal.pone.0107919https://doaj.org/article/39bae2d52e844cd0b54cac19d6cea3d42014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107919https://doaj.org/toc/1932-6203<h4>Background</h4>The incidence of Post-CABG atrial fibrillation (AF) lies between 25% and 40%. It worsens morbidity and raises post-operative costs. Detection of incoming AF soon enough for prophylactic intervention would be helpful. The study is to investigate the electrophysiological changes preceding the onset of AF and their relationship to the preoperative risk.<h4>Methods and results</h4>Patients were recorded continuously for the first four days after coronary artery bypass grafting surgery (CABG) with three unipolar electrodes sutured to the atria (AEG). The patients experiencing an AF lasting more than 10 minutes were selected and the two hours before the onset were analyzed. Four variables were found to show significant changes in the two hours prior to the first prolonged AF: increasing rate of premature atrial activation, increasing incidence of short transient arrhythmias, acceleration of heart rate, and rise of low frequency content of heart rate. The main contrast was between the first and last hour before AF onset. Preoperative risk was not predictive of the onset time of AF and did not correlate with the amplitude of changes prior to AF.<h4>Conclusions</h4>Post-CABG AF were preceded by electrophysiological changes occurring in the last hour before the onset of the arrhythmia, whereas none of these changes was found to occur in all AF patients. The risk was a weighted sum of factors related to the density of premature activations and the state of atrial substrate reflected by the sinus rhythm and its frequency content prior to AF. Preoperative risk score seems unhelpful in setting a detection threshold for the AF onset.Feng XiongYalin YinBruno DubéPierre PagéAlain VinetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107919 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng Xiong Yalin Yin Bruno Dubé Pierre Pagé Alain Vinet Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
description	<h4>Background</h4>The incidence of Post-CABG atrial fibrillation (AF) lies between 25% and 40%. It worsens morbidity and raises post-operative costs. Detection of incoming AF soon enough for prophylactic intervention would be helpful. The study is to investigate the electrophysiological changes preceding the onset of AF and their relationship to the preoperative risk.<h4>Methods and results</h4>Patients were recorded continuously for the first four days after coronary artery bypass grafting surgery (CABG) with three unipolar electrodes sutured to the atria (AEG). The patients experiencing an AF lasting more than 10 minutes were selected and the two hours before the onset were analyzed. Four variables were found to show significant changes in the two hours prior to the first prolonged AF: increasing rate of premature atrial activation, increasing incidence of short transient arrhythmias, acceleration of heart rate, and rise of low frequency content of heart rate. The main contrast was between the first and last hour before AF onset. Preoperative risk was not predictive of the onset time of AF and did not correlate with the amplitude of changes prior to AF.<h4>Conclusions</h4>Post-CABG AF were preceded by electrophysiological changes occurring in the last hour before the onset of the arrhythmia, whereas none of these changes was found to occur in all AF patients. The risk was a weighted sum of factors related to the density of premature activations and the state of atrial substrate reflected by the sinus rhythm and its frequency content prior to AF. Preoperative risk score seems unhelpful in setting a detection threshold for the AF onset.
format	article
author	Feng Xiong Yalin Yin Bruno Dubé Pierre Pagé Alain Vinet
author_facet	Feng Xiong Yalin Yin Bruno Dubé Pierre Pagé Alain Vinet
author_sort	Feng Xiong
title	Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
title_short	Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
title_full	Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
title_fullStr	Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
title_full_unstemmed	Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
title_sort	electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/39bae2d52e844cd0b54cac19d6cea3d4
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Electrophysiological changes preceding the onset of atrial fibrillation after coronary bypass grafting surgery.

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