Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

Recent studies have utilized bulk tumour mRNA sequencing to classify bladder cancers into distinct subgroups. Here, the authors use single cell transcriptomic analysis and cell transplant studies to show that epithelial plasticity can generate basal, luminal and mesenchymal phenotypes in human and m...

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Autores principales:	John P. Sfakianos, Jorge Daza, Yang Hu, Harry Anastos, Geoffrey Bryant, Rohan Bareja, Ketan K. Badani, Matthew D. Galsky, Olivier Elemento, Bishoy M. Faltas, David J. Mulholland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39bc9eb083864859b7b514bb4bf04fc8
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spelling	oai:doaj.org-article:39bc9eb083864859b7b514bb4bf04fc82021-12-02T15:53:08ZEpithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers10.1038/s41467-020-16162-32041-1723https://doaj.org/article/39bc9eb083864859b7b514bb4bf04fc82020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16162-3https://doaj.org/toc/2041-1723Recent studies have utilized bulk tumour mRNA sequencing to classify bladder cancers into distinct subgroups. Here, the authors use single cell transcriptomic analysis and cell transplant studies to show that epithelial plasticity can generate basal, luminal and mesenchymal phenotypes in human and murine bladder cancers.John P. SfakianosJorge DazaYang HuHarry AnastosGeoffrey BryantRohan BarejaKetan K. BadaniMatthew D. GalskyOlivier ElementoBishoy M. FaltasDavid J. MulhollandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John P. Sfakianos Jorge Daza Yang Hu Harry Anastos Geoffrey Bryant Rohan Bareja Ketan K. Badani Matthew D. Galsky Olivier Elemento Bishoy M. Faltas David J. Mulholland Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
description	Recent studies have utilized bulk tumour mRNA sequencing to classify bladder cancers into distinct subgroups. Here, the authors use single cell transcriptomic analysis and cell transplant studies to show that epithelial plasticity can generate basal, luminal and mesenchymal phenotypes in human and murine bladder cancers.
format	article
author	John P. Sfakianos Jorge Daza Yang Hu Harry Anastos Geoffrey Bryant Rohan Bareja Ketan K. Badani Matthew D. Galsky Olivier Elemento Bishoy M. Faltas David J. Mulholland
author_facet	John P. Sfakianos Jorge Daza Yang Hu Harry Anastos Geoffrey Bryant Rohan Bareja Ketan K. Badani Matthew D. Galsky Olivier Elemento Bishoy M. Faltas David J. Mulholland
author_sort	John P. Sfakianos
title	Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
title_short	Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
title_full	Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
title_fullStr	Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
title_full_unstemmed	Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
title_sort	epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/39bc9eb083864859b7b514bb4bf04fc8
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Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

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