Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease

Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease

Jiangtao Zhang,1,2 Zhongwei Guo,2 Xiaozheng Liu,3 Xize Jia,4 Jiapeng Li,2 Yaoyao Li,1,5 Danmei Lv,1,5 Wei Chen1,5 1Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China; 2Tongd...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhang J, Guo Z, Liu X, Jia X, Li J, Li Y, Lv D, Chen W
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Alzheimer’s disease
Depressive symptoms
Resting-state functional MRI
PCC
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/39be24c815564f40a39d4662cf54bc5d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:39be24c815564f40a39d4662cf54bc5d
record_format dspace
spelling oai:doaj.org-article:39be24c815564f40a39d4662cf54bc5d2021-12-02T00:37:40ZAbnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease1178-2021https://doaj.org/article/39be24c815564f40a39d4662cf54bc5d2017-10-01T00:00:00Zhttps://www.dovepress.com/abnormal-functional-connectivity-of-the-posterior-cingulate-cortex-is--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jiangtao Zhang,1,2 Zhongwei Guo,2 Xiaozheng Liu,3 Xize Jia,4 Jiapeng Li,2 Yaoyao Li,1,5 Danmei Lv,1,5 Wei Chen1,5 1Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China; 2Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China; 3China-USA Neuroimaging Research Institute & Department of Radiology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; 4Center for Cognitive Brain Disorders & Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China; 5Key Laboratory of Medical Neurobiology of Chinese Ministry of Health, Hangzhou, Zhejiang, China Background: Depressive symptoms are significant and very common psychiatric complications in patients with Alzheimer’s disease (AD), which can aggravate the decline in social function. However, changes in the functional connectivity (FC) of the brain in AD patients with depressive symptoms (D-AD) remain unclear.Objective: To investigate whether any differences exist in the FC of the posterior cingulate cortex (PCC) between D-AD patients and non-depressed AD patients (nD-AD).Materials and methods: We recruited 15 D-AD patients and 17 age-, sex-, educational level-, and Mini-Mental State Examination (MMSE)-matched nD-AD patients to undergo tests using the Neuropsychiatric Inventory, Hamilton Depression Rating Scale, and 3.0T resting-state functional magnetic resonance imaging. Bilateral PCC were selected as the regions of interest and between-group differences in the PCC FC network were assessed using Student’s t-test.Results: Compared with the nD-AD group, D-AD patients showed increased PCC FC in the right amygdala, right parahippocampus, right superior temporal pole, right middle temporal lobe, right middle temporal pole, and right hippocampus (AlphaSim correction; P<0.05). In the nD-AD group, MMSE scores were positively correlated with PCC FC in the right superior temporal pole and right hippocampus (false discovery rate corrected; P<0.05).Conclusion: Differences were detected in PCC FC between nD-AD and D-AD patients, which may be related to depressive symptoms. Our study provides a significant enhancement to our understanding of the functional mechanisms underlying D-AD. Keywords: Alzheimer’s disease, depressive symptoms, resting-state functional MRI, PCCZhang JGuo ZLiu XJia XLi JLi YLv DChen WDove Medical PressarticleAlzheimer’s diseaseDepressive symptomsResting-state functional MRIPCCNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2589-2598 (2017)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer’s disease
Depressive symptoms
Resting-state functional MRI
PCC
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Alzheimer’s disease
Depressive symptoms
Resting-state functional MRI
PCC
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Zhang J
Guo Z
Liu X
Jia X
Li J
Li Y
Lv D
Chen W
Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
description Jiangtao Zhang,1,2 Zhongwei Guo,2 Xiaozheng Liu,3 Xize Jia,4 Jiapeng Li,2 Yaoyao Li,1,5 Danmei Lv,1,5 Wei Chen1,5 1Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang, China; 2Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China; 3China-USA Neuroimaging Research Institute & Department of Radiology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; 4Center for Cognitive Brain Disorders & Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China; 5Key Laboratory of Medical Neurobiology of Chinese Ministry of Health, Hangzhou, Zhejiang, China Background: Depressive symptoms are significant and very common psychiatric complications in patients with Alzheimer’s disease (AD), which can aggravate the decline in social function. However, changes in the functional connectivity (FC) of the brain in AD patients with depressive symptoms (D-AD) remain unclear.Objective: To investigate whether any differences exist in the FC of the posterior cingulate cortex (PCC) between D-AD patients and non-depressed AD patients (nD-AD).Materials and methods: We recruited 15 D-AD patients and 17 age-, sex-, educational level-, and Mini-Mental State Examination (MMSE)-matched nD-AD patients to undergo tests using the Neuropsychiatric Inventory, Hamilton Depression Rating Scale, and 3.0T resting-state functional magnetic resonance imaging. Bilateral PCC were selected as the regions of interest and between-group differences in the PCC FC network were assessed using Student’s t-test.Results: Compared with the nD-AD group, D-AD patients showed increased PCC FC in the right amygdala, right parahippocampus, right superior temporal pole, right middle temporal lobe, right middle temporal pole, and right hippocampus (AlphaSim correction; P<0.05). In the nD-AD group, MMSE scores were positively correlated with PCC FC in the right superior temporal pole and right hippocampus (false discovery rate corrected; P<0.05).Conclusion: Differences were detected in PCC FC between nD-AD and D-AD patients, which may be related to depressive symptoms. Our study provides a significant enhancement to our understanding of the functional mechanisms underlying D-AD. Keywords: Alzheimer’s disease, depressive symptoms, resting-state functional MRI, PCC
format article
author Zhang J
Guo Z
Liu X
Jia X
Li J
Li Y
Lv D
Chen W
author_facet Zhang J
Guo Z
Liu X
Jia X
Li J
Li Y
Lv D
Chen W
author_sort Zhang J
title Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
title_short Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
title_full Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
title_fullStr Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
title_full_unstemmed Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease
title_sort abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with alzheimer’s disease
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/39be24c815564f40a39d4662cf54bc5d
work_keys_str_mv AT zhangj abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT guoz abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT liux abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT jiax abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT lij abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT liy abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT lvd abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
AT chenw abnormalfunctionalconnectivityoftheposteriorcingulatecortexisassociatedwithdepressivesymptomsinpatientswithalzheimerrsquosdisease
_version_ 1718403608339283968

Ejemplares similares