The effects of Nicotine on licking behavior induced by Apomorphine in rats

Objective: The purpose of the present study was to determine the possible interaction of nicotine or muscarinic receptor mechanism(s) with the licking behavior induced by apomorphine in rats. Methods: Rats (150-250 g) were treated with saline or different doses of apomorphine and nicotine, mecamylam...

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Autores principales:	MR Zarrindast, M Shecharchi, M Rezayat
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 1999
Materias:	nicotine apomorphine cholinergic nicotinic antagonists licking rats Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/39bf3d15a49f410fb12168e4488c8e91
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spelling	oai:doaj.org-article:39bf3d15a49f410fb12168e4488c8e912021-11-10T09:24:31ZThe effects of Nicotine on licking behavior induced by Apomorphine in rats1561-41072251-7170https://doaj.org/article/39bf3d15a49f410fb12168e4488c8e911999-10-01T00:00:00Zhttp://jbums.org/article-1-2935-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: The purpose of the present study was to determine the possible interaction of nicotine or muscarinic receptor mechanism(s) with the licking behavior induced by apomorphine in rats. Methods: Rats (150-250 g) were treated with saline or different doses of apomorphine and nicotine, mecamylamine, hexamethonium and atropine. Licking was recorded during a period of 60 min dafter injection. One and two-way ANOVA followed by Newman-Keuls test were used for data analysis. Difference with P<0.05 between experimental groups at each point was considered statistically significant. Findings: In present study, the dopaminergic receptor agonist apomorphine (0.1, 0.25 and 0.5 mg/kg) induced a dose-dependent licking in rats. Nicotine administration (0.025-250 mg/kg) altered the apomorphine-induced licking. The lower doses of nicotinic (0.05 and 0.5 mg/kg) increased the apomorphine response while the higher dose (250 mg/kg) reduced it. The anti-muscarinic drug atropine (2.5 and 5 mg/kg) reduced the effects of apomorphine or nicotine plus apomorphine. The central nicotine receptor antagonist mecamylamine (0.05, 0.25 and 0.5 mg/kg) also reduced the response induced by apomorphine alone or together with nicotine. However, the peripheral nicotinic receptor antagonist hexamethonium (2.5, 5 and 10 mg/kg) reduced the response induced by nicotine plus apomorphine but not that elicited by apomorphine alone. Conclusion: The results indicate that the nicotinic receptor mechanism(s) may interact with apomorphine-induced licking in rats. Although central nicotinic and cholinergic mechanisms may be involved in the licking induce Med by apomorphine, peripheral nicotinic mechanism may be involved in the increased apomorphine effect induced by nicotine.MR ZarrindastM ShecharchiM RezayatBabol University of Medical SciencesarticlenicotineapomorphinecholinergicnicotinicantagonistslickingratsMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 1, Iss 4, Pp 8-13 (1999)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	nicotine apomorphine cholinergic nicotinic antagonists licking rats Medicine R Medicine (General) R5-920
spellingShingle	nicotine apomorphine cholinergic nicotinic antagonists licking rats Medicine R Medicine (General) R5-920 MR Zarrindast M Shecharchi M Rezayat The effects of Nicotine on licking behavior induced by Apomorphine in rats
description	Objective: The purpose of the present study was to determine the possible interaction of nicotine or muscarinic receptor mechanism(s) with the licking behavior induced by apomorphine in rats. Methods: Rats (150-250 g) were treated with saline or different doses of apomorphine and nicotine, mecamylamine, hexamethonium and atropine. Licking was recorded during a period of 60 min dafter injection. One and two-way ANOVA followed by Newman-Keuls test were used for data analysis. Difference with P<0.05 between experimental groups at each point was considered statistically significant. Findings: In present study, the dopaminergic receptor agonist apomorphine (0.1, 0.25 and 0.5 mg/kg) induced a dose-dependent licking in rats. Nicotine administration (0.025-250 mg/kg) altered the apomorphine-induced licking. The lower doses of nicotinic (0.05 and 0.5 mg/kg) increased the apomorphine response while the higher dose (250 mg/kg) reduced it. The anti-muscarinic drug atropine (2.5 and 5 mg/kg) reduced the effects of apomorphine or nicotine plus apomorphine. The central nicotine receptor antagonist mecamylamine (0.05, 0.25 and 0.5 mg/kg) also reduced the response induced by apomorphine alone or together with nicotine. However, the peripheral nicotinic receptor antagonist hexamethonium (2.5, 5 and 10 mg/kg) reduced the response induced by nicotine plus apomorphine but not that elicited by apomorphine alone. Conclusion: The results indicate that the nicotinic receptor mechanism(s) may interact with apomorphine-induced licking in rats. Although central nicotinic and cholinergic mechanisms may be involved in the licking induce Med by apomorphine, peripheral nicotinic mechanism may be involved in the increased apomorphine effect induced by nicotine.
format	article
author	MR Zarrindast M Shecharchi M Rezayat
author_facet	MR Zarrindast M Shecharchi M Rezayat
author_sort	MR Zarrindast
title	The effects of Nicotine on licking behavior induced by Apomorphine in rats
title_short	The effects of Nicotine on licking behavior induced by Apomorphine in rats
title_full	The effects of Nicotine on licking behavior induced by Apomorphine in rats
title_fullStr	The effects of Nicotine on licking behavior induced by Apomorphine in rats
title_full_unstemmed	The effects of Nicotine on licking behavior induced by Apomorphine in rats
title_sort	effects of nicotine on licking behavior induced by apomorphine in rats
publisher	Babol University of Medical Sciences
publishDate	1999
url	https://doaj.org/article/39bf3d15a49f410fb12168e4488c8e91
work_keys_str_mv	AT mrzarrindast theeffectsofnicotineonlickingbehaviorinducedbyapomorphineinrats AT mshecharchi theeffectsofnicotineonlickingbehaviorinducedbyapomorphineinrats AT mrezayat theeffectsofnicotineonlickingbehaviorinducedbyapomorphineinrats AT mrzarrindast effectsofnicotineonlickingbehaviorinducedbyapomorphineinrats AT mshecharchi effectsofnicotineonlickingbehaviorinducedbyapomorphineinrats AT mrezayat effectsofnicotineonlickingbehaviorinducedbyapomorphineinrats
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The effects of Nicotine on licking behavior induced by Apomorphine in rats

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