Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environment...
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Nature Portfolio
2016
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oai:doaj.org-article:39c2f9d37bab46039537980e86d2c5622021-12-02T17:32:23ZSphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia10.1038/ncomms120862041-1723https://doaj.org/article/39c2f9d37bab46039537980e86d2c5622016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12086https://doaj.org/toc/2041-1723The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans.Kaiqi SunYujin ZhangAngelo D’AlessandroTravis NemkovAnren SongHongyu WuHong LiuMorayo AdebiyiAji HuangYuan E. WenMikhail V. BogdanovAlejandro VilaJohn O’BrienRodney E. KellemsWilliam DowhanAndrew W. SubudhiSonja Jameson-Van HoutenColleen G. JulianAndrew T. LoveringMartin SafoKirk C. HansenRobert C. RoachYang XiaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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| topic |
Science Q |
| spellingShingle |
Science Q Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| description |
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans. |
| format |
article |
| author |
Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia |
| author_facet |
Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia |
| author_sort |
Kaiqi Sun |
| title |
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_short |
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_full |
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_fullStr |
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_full_unstemmed |
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_sort |
sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/39c2f9d37bab46039537980e86d2c562 |
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