Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice

Abstract Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate...

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Autores principales: Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, Doo Hee Han
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/39c4ddd78b11421a817792eb5db58ab7
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spelling oai:doaj.org-article:39c4ddd78b11421a817792eb5db58ab72021-12-02T15:08:39ZDiesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice10.1038/s41598-021-94673-92045-2322https://doaj.org/article/39c4ddd78b11421a817792eb5db58ab72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94673-9https://doaj.org/toc/2045-2322Abstract Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.Hahn Jin JungYoung-Kyung KoWoo Sub ShimHyun Jik KimDong-Young KimChae-Seo RheeMoo Kyun ParkDoo Hee HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hahn Jin Jung
Young-Kyung Ko
Woo Sub Shim
Hyun Jik Kim
Dong-Young Kim
Chae-Seo Rhee
Moo Kyun Park
Doo Hee Han
Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
description Abstract Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.
format article
author Hahn Jin Jung
Young-Kyung Ko
Woo Sub Shim
Hyun Jik Kim
Dong-Young Kim
Chae-Seo Rhee
Moo Kyun Park
Doo Hee Han
author_facet Hahn Jin Jung
Young-Kyung Ko
Woo Sub Shim
Hyun Jik Kim
Dong-Young Kim
Chae-Seo Rhee
Moo Kyun Park
Doo Hee Han
author_sort Hahn Jin Jung
title Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
title_short Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
title_full Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
title_fullStr Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
title_full_unstemmed Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
title_sort diesel exhaust particles increase nasal symptoms and il-17a in house dust mite-induced allergic mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/39c4ddd78b11421a817792eb5db58ab7
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