Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhi...

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Autores principales: Lesley Cheng, Camelia Quek, Xia Li, Shayne A. Bellingham, Laura J. Ellett, Mitch Shambrook, Saima Zafar, Inga Zerr, Victoria A. Lawson, Andrew F. Hill
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/39c8cfc317f54c2eb8c47b3a23e018f6
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Sumario:Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhibiting prion infectivity.