Treating Metastatic Brain Cancers With Stem Cells

Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory res...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nadia Sadanandan, Alex Shear, Beverly Brooks, Madeline Saft, Dorothy Anne Galang Cabantan, Chase Kingsbury, Henry Zhang, Stefan Anthony, Zhen-Jie Wang, Felipe Esparza Salazar, Alma R. Lezama Toledo, Germán Rivera Monroy, Joaquin Vega Gonzales-Portillo, Alexa Moscatello, Jea-Young Lee, Cesario V. Borlongan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	blood brain barrier melanoma brain metastases stem cell therapy bone marrow derived mesenchymal stem cell endothelial progenitor cell Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/39cba048fef04af98ebce458c103aff1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39cba048fef04af98ebce458c103aff1
record_format	dspace
spelling	oai:doaj.org-article:39cba048fef04af98ebce458c103aff12021-11-30T17:47:00ZTreating Metastatic Brain Cancers With Stem Cells1662-509910.3389/fnmol.2021.749716https://doaj.org/article/39cba048fef04af98ebce458c103aff12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.749716/fullhttps://doaj.org/toc/1662-5099Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory responses associated with BBB damage secondary to tumoral activity, we identify the involvement of this pathological process in the growth and formation of metastatic brain cancers. Likewise, we evaluate the hypothesis of regenerating impaired endothelial cells of the BBB and alleviating the damaged neurovascular unit to attenuate brain metastasis, using the endothelial progenitor cell (EPC) phenotype of bone marrow-derived mesenchymal stem cells. Specifically, there is a need to evaluate the efficacy for stem cell therapy to repair disruptions in the BBB and reduce inflammation in the brain, thereby causing attenuation of metastatic brain cancers. To establish the viability of stem cell therapy for the prevention and treatment of metastatic brain tumors, it is crucial to demonstrate BBB repair through augmentation of vasculogenesis and angiogenesis. BBB disruption is strongly linked to metastatic melanoma, worsens neuroinflammation during metastasis, and negatively influences the prognosis of metastatic brain cancer. Using stem cell therapy to interrupt inflammation secondary to this leaky BBB represents a paradigm-shifting approach for brain cancer treatment. In this review article, we critically assess the advantages and disadvantages of using stem cell therapy for brain metastases and glioblastoma.Nadia SadanandanAlex ShearBeverly BrooksMadeline SaftDorothy Anne Galang CabantanChase KingsburyHenry ZhangStefan AnthonyZhen-Jie WangFelipe Esparza SalazarAlma R. Lezama ToledoGermán Rivera MonroyJoaquin Vega Gonzales-PortilloAlexa MoscatelloJea-Young LeeCesario V. BorlonganCesario V. BorlonganFrontiers Media S.A.articleblood brain barriermelanomabrain metastasesstem cell therapybone marrow derived mesenchymal stem cellendothelial progenitor cellNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood brain barrier melanoma brain metastases stem cell therapy bone marrow derived mesenchymal stem cell endothelial progenitor cell Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	blood brain barrier melanoma brain metastases stem cell therapy bone marrow derived mesenchymal stem cell endothelial progenitor cell Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Nadia Sadanandan Alex Shear Beverly Brooks Madeline Saft Dorothy Anne Galang Cabantan Chase Kingsbury Henry Zhang Stefan Anthony Zhen-Jie Wang Felipe Esparza Salazar Alma R. Lezama Toledo Germán Rivera Monroy Joaquin Vega Gonzales-Portillo Alexa Moscatello Jea-Young Lee Cesario V. Borlongan Cesario V. Borlongan Treating Metastatic Brain Cancers With Stem Cells
description	Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory responses associated with BBB damage secondary to tumoral activity, we identify the involvement of this pathological process in the growth and formation of metastatic brain cancers. Likewise, we evaluate the hypothesis of regenerating impaired endothelial cells of the BBB and alleviating the damaged neurovascular unit to attenuate brain metastasis, using the endothelial progenitor cell (EPC) phenotype of bone marrow-derived mesenchymal stem cells. Specifically, there is a need to evaluate the efficacy for stem cell therapy to repair disruptions in the BBB and reduce inflammation in the brain, thereby causing attenuation of metastatic brain cancers. To establish the viability of stem cell therapy for the prevention and treatment of metastatic brain tumors, it is crucial to demonstrate BBB repair through augmentation of vasculogenesis and angiogenesis. BBB disruption is strongly linked to metastatic melanoma, worsens neuroinflammation during metastasis, and negatively influences the prognosis of metastatic brain cancer. Using stem cell therapy to interrupt inflammation secondary to this leaky BBB represents a paradigm-shifting approach for brain cancer treatment. In this review article, we critically assess the advantages and disadvantages of using stem cell therapy for brain metastases and glioblastoma.
format	article
author	Nadia Sadanandan Alex Shear Beverly Brooks Madeline Saft Dorothy Anne Galang Cabantan Chase Kingsbury Henry Zhang Stefan Anthony Zhen-Jie Wang Felipe Esparza Salazar Alma R. Lezama Toledo Germán Rivera Monroy Joaquin Vega Gonzales-Portillo Alexa Moscatello Jea-Young Lee Cesario V. Borlongan Cesario V. Borlongan
author_facet	Nadia Sadanandan Alex Shear Beverly Brooks Madeline Saft Dorothy Anne Galang Cabantan Chase Kingsbury Henry Zhang Stefan Anthony Zhen-Jie Wang Felipe Esparza Salazar Alma R. Lezama Toledo Germán Rivera Monroy Joaquin Vega Gonzales-Portillo Alexa Moscatello Jea-Young Lee Cesario V. Borlongan Cesario V. Borlongan
author_sort	Nadia Sadanandan
title	Treating Metastatic Brain Cancers With Stem Cells
title_short	Treating Metastatic Brain Cancers With Stem Cells
title_full	Treating Metastatic Brain Cancers With Stem Cells
title_fullStr	Treating Metastatic Brain Cancers With Stem Cells
title_full_unstemmed	Treating Metastatic Brain Cancers With Stem Cells
title_sort	treating metastatic brain cancers with stem cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/39cba048fef04af98ebce458c103aff1
work_keys_str_mv	AT nadiasadanandan treatingmetastaticbraincancerswithstemcells AT alexshear treatingmetastaticbraincancerswithstemcells AT beverlybrooks treatingmetastaticbraincancerswithstemcells AT madelinesaft treatingmetastaticbraincancerswithstemcells AT dorothyannegalangcabantan treatingmetastaticbraincancerswithstemcells AT chasekingsbury treatingmetastaticbraincancerswithstemcells AT henryzhang treatingmetastaticbraincancerswithstemcells AT stefananthony treatingmetastaticbraincancerswithstemcells AT zhenjiewang treatingmetastaticbraincancerswithstemcells AT felipeesparzasalazar treatingmetastaticbraincancerswithstemcells AT almarlezamatoledo treatingmetastaticbraincancerswithstemcells AT germanriveramonroy treatingmetastaticbraincancerswithstemcells AT joaquinvegagonzalesportillo treatingmetastaticbraincancerswithstemcells AT alexamoscatello treatingmetastaticbraincancerswithstemcells AT jeayounglee treatingmetastaticbraincancerswithstemcells AT cesariovborlongan treatingmetastaticbraincancerswithstemcells AT cesariovborlongan treatingmetastaticbraincancerswithstemcells
_version_	1718406372785127424

Treating Metastatic Brain Cancers With Stem Cells

Ejemplares similares